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上海信裕生物科技有限公司
OPTN抗体

OPTN抗体

商家询价

产品名称： OPTN抗体

英文名称： OPTNAntibody

产品编号： XY10837-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 OPTN抗体Applications

In-house applications ELISA, WB, IHC, IF, IP, FC     Application not tested? Please see our Guarantee.
Published applications IHC, WB Publications 7 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human, mouse
Images
Prev12NextView more validation data
  • 10837-1-AP;HeLa cellsHeLa cells were subjected to SDS PAGE followed by western blot with 10837-1-AP(OPTN antibody) at dilution of 1:800
  • 10837-1-AP;mouse brain tissueIP Result of anti-OPTN (IP:10837-1-AP, 3ug; Detection:10837-1-AP 1:800) with mouse brain tissue lysate 8000ug.
  • 10837-1-AP;human pancreas cancerImmunohistochemical of paraffin-embedded human pancreas cancer using 10837-1-AP(OPTN antibody) at dilution of 1:50 (under 10x lens)
  • 10837-1-AP;human pancreas cancerImmunohistochemical of paraffin-embedded human pancreas cancer using 10837-1-AP(OPTN antibody) at dilution of 1:50 (under 40x lens)
  • 10837-1-AP;MCF-7Immunofluorescent analysis of MCF-7 cells, using OPTN antibody 10837-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
  • 10837-1-AP;MCF-7 cells1X10^6 MCF-7 cells were stained with 0.2ug OPTN antibody (10837-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
Positive WB detected in HeLa cells, mouse brain tissue, mouse testis tissue
Positive IP detected in Mouse brain tissue
Positive IHC detected in Human pancreas cancer tissue, human brain tissue
Positive IF detected in MCF-7 cells
Positive FC detected in MCF-7 cells
Recommended dilution WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100
 OPTN抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen OPTN fusion protein ag1272 Full name Optineurin
Calculated molecular
weight		 66 kDa Observed molecular 
weight		 66 kDa
GenBank accession 
number		 BC013876 Gene ID (NCBI) 10133
Gene symbol OPTN Synonyms E3 14.7K interacting protein, FIP 2, FIP2, GLC1E, HIP 7, HIP7, Huntingtin yeast partner L, HYPL, NEMO related protein, NRP, optineurin, OPTN, TFIIIA INTP
Background OPTN抗体

OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork. OPTN抗体

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