FITC标记的螺旋转录因子OTP抗体
产品名称： FITC标记的螺旋转录因子OTP抗体
英文名称： Anti-OTP/FITC
产品编号： HZ-11920R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-OTP/FITC Conjugated antibody
FITC标记的螺旋转录因子OTP抗体
| 英文名称 | Anti-OTP/FITC |
| 中文名称 | FITC标记的螺旋转录因子OTP抗体 |
| 别 名 | MGC3161; orthopedia homeobox; orthopedia homolog; OTP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Fruit Fly, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OTP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Homeodomain (HD) genes are helix-turn-helix transcription factors that play key roles in the specification of cell fates. OTP (orthopedia homeobox) is a 325 amino acid nuclear protein belonging to the paired homeobox family and Bicoid subfamily. OTP is expressed in neurons, which give rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV) and arcuate (ARN) nuclei. Containing a homeobox DNA-binding domain and a OAR domain, OTP is suggested to be involved in the differentiation of hypothalamic neuroendocrine cells. At early embryonic stages in mice, the expression of SIM2 is downregulated in the absence of OTP, indicating a potential role for OTP as an upstream regulator of SIM2. OTP is highly conserved in evolution and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Function: OTP is a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. Subcellular Location: Nuclear Similarity: Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: Q5XKR4.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
同源域（HD）基因是在细胞命运规范中起关键作用的螺旋-转轮-螺旋转录因子。OTP（OptoPopa同源盒）是属于同源同源盒家族和双分子亚家族的325个氨基酸核蛋白。OTP在神经元中表达，这些神经元产生室旁核（PVN）、视上核（SON）、前室周核（aPV）和弓状核（ARN）。OTP具有同源盒DNA结合结构域和OAR结构域，可能参与下丘脑神经内分泌细胞的分化。在小鼠胚胎的早期阶段，在没有OTP的情况下，SIM2的表达下调，表明OTP作为SIM2的上游调节因子具有潜在的作用。OTP在进化过程中高度保守，由位于人类5号染色体上的基因编码，该基因包含1.81亿个碱基对，占人类基因组的近6％。