DUSP13,双特异性磷酸酶13抗体

产品编号HZ-7797R
英文名称DUSP13
中文名称双特异性磷酸酶13抗体
别 名BEDP; Branching enzyme interacting dual specificity protein phosphatase; Dual specificity phosphatase 13; Dual specificity phosphatase SKRP4; DUSP13A; DUSP13B; FLJ32450; MDSP; Muscle restricted dual specificity phosphatase; SKRP4; Testis and skeletal muscle specific DSP; TMDP; DUS13_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 信号转导 细胞周期蛋白 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Cow, Sheep,
DUSP13,双特异性磷酸酶13抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DUSP13
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DUSP13,双特异性磷酸酶13抗体PubMedPubMed
产品介绍background:
Members of the protein-tyrosine phosphatase superfamilycooperate with protein kinases to regulate cell proliferation anddifferentiation. This superfamily is separated into two familiesbased on the substrate that is dephosphorylated. One family, thedual specificity phosphatases (DSPs) acts on both phosphotyrosineand phosphoserine/threonine residues. This gene encodes differentbut related DSP proteins through the use of non-overlapping openreading frames, alternate splicing, and presumed differenttranscription promoters. Expression of the distinct proteins fromthis gene has been found to be tissue specific and the proteins maybe involved in postnatal development of specific tissues. A proteinencoded by the upstream ORF was found in skeletal muscle, whereasthe encoded protein from the downstream ORF was found only intestis. In mouse, a similar pattern of expression was found.Multiple alternatively spliced transcript variants were described,but the full-length sequence of only some were determined.[provided by RefSeq, Jul 2008].

Function:
May be involved in the regulation of meiosis and/ordifferentiation of testicular germ cells during spermatogenesis.Exhibits intrinsic phosphatase activity towards bothphospho-seryl/threonyl and -tyrosyl residues of myelin basicprotein, with similar specific activities in vitro.

Tissue Specificity:
Most abundantly expressed in the testis. Alsofound in the skeletal muscle. Testis-specific (at protein level).

DUSP13,双特异性磷酸酶13抗体Similarity:
Belongs to the protein-tyrosine phosphatase family.Non-receptor class dual specificity subfamily.
Contains 1 tyrosine-protein phosphatase domain.

Database links:
UniProtKB/Swiss-Prot: Q9UII6.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.