AUP1,原始广泛存在蛋白1抗体

产品编号HZ-7550R
英文名称AUP1
中文名称原始广泛存在蛋白1抗体
别 名AA589454; AUP 1; AUP1; AUP1_HUMAN; Ancient ubiquitous protein 1.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
AUP1,原始广泛存在蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AUP1/Ancient ubiquitous protein 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AUP1,原始广泛存在蛋白1抗体PubMedPubMed
产品介绍background:
Ancient ubiquitous protein 1 (AUP1) contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. It has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits.

Function:
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Subunit:
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.

Tissue Specificity:
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.

Similarity:
Belongs to the AUP1 family.
Contains 1 CUE domain.

Gene ID:
550

AUP1,原始广泛存在蛋白1抗体Database links:
Entrez Gene: 550 Human
Entrez Gene: 11993 Mouse
Entrez Gene: 680423 Rat
Omim: 602434 Human
SwissProt: Q9Y679 Human
SwissProt: P70295 Mouse
SwissProt: A1L134 Rat
Unigene: 411480 Human
Unigene: 386752 Mouse
Unigene: 198163 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.