FITC标记的转录调节因子MAZR抗体
产品名称： FITC标记的转录调节因子MAZR抗体
英文名称： Anti-PATZ1/FITC
产品编号： HZ-5920R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PATZ1/FITC Conjugated antibody
FITC标记的转录调节因子MAZR抗体
| 英文名称 | Anti-PATZ1/FITC |
| 中文名称 | FITC标记的转录调节因子MAZR抗体 |
| 别 名 | BTB POZ domain zinc finger transcription factor; Mazr; PATZ; POZ (BTB) and AT hook containing zinc finger 1; POZ , AT hook, and zinc finger containing protein 1; Protein kinase A RI subunit alpha associated protein; RIAZ; Transcription factor MAZR; ZBTB19; Zfp278; Zinc finger and BTB domain containing protein 19; Zinc finger protein 278; Zinc finger protein 278, isoform CRA_d; Zinc finger sarcoma gene protein; ZNF278; ZSG. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 74kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PATZ1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12).The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 1 A.T hook DNA-binding domain. Contains 1 BTB (POZ) domain. Contains 7 C2H2-type zinc fingers. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PATZ1包含A -T钩体DNA结合基序，通常结合其他DNA结合结构在染色质建模和转录调控中发挥重要作用。其PZZ结构域被认为是蛋白质-蛋白质相互作用的位点，是转录抑制所必需的，锌指包含DNA结合结构域。由于编码的蛋白质具有转录因子的典型特征，因此推测它是基因表达的阻遏物。在小圆形细胞肉瘤中，该基因通过22q的小反转被融合到EWS，然后被认为是易位（t（1；22）（p31.1；q12）），由该基因编码的蛋白质包含一个与其他DNA结合结构结合的A- T钩DNA结合基序，以发挥重要作用。在染色质建模和转录调控。其PZZ结构域被认为是蛋白质-蛋白质相互作用的位点，是转录抑制所必需的，锌指包含DNA结合结构域。由于编码的蛋白质具有转录因子的典型特征，因此推测它是基因表达的阻遏物。在小圆形细胞肉瘤中，该基因通过22q的小反转被融合到EWS，然后认为杂种转移（t（1；22））（p31.1；q12）。第22号染色体的重排涉及该基因的EWS和第1外显子8的内含子，其产生嵌合序列，该序列包含EWS的反式激活域与该蛋白的锌指结构域融合。这是染色体22内染色体重排的一个明显例子。该基因描述了四种交替剪接转录变体。