FITC标记的CD361抗体
产品名称： FITC标记的CD361抗体
英文名称： Anti-CD361/FITC
产品编号： HZ-14684R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CD361/FITC Conjugated antibody
FITC标记的CD361抗体
| 英文名称 | Anti-CD361/FITC |
| 中文名称 | FITC标记的CD361抗体 |
| 别 名 | EVI2B; CD361; D17S376; Ecotropic viral integration site 2B; Ecotropic viral integration site 2B protein homolog; EVDB; EVI 2B; EVI-2B; Evi2b; EVI2B protein; EVI2B_HUMAN; Protein EVI2B. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD361 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: EVI2B is a 448 amino acid protein which functions in the differentiation of melanocytes and keratinocytes. Lying within an intron of the Neurofibromin gene, the gene encoding EVI2B is transcribed from the telomere toward the centromere, which is opposite the transcription direction of the Neurofibromin gene. EVI2B is a single-pass transmembrane protein containing an extracellular domain with 4 glycosylation sites, a N-terminal signal peptide, a cytoplasmic hydrophilic domain and a hydrophobic transmembrane domain. Due to evidence suggesting that gene encoding the mouse homolog lies within a viral integration site that has been identitified in retrovirus-induced myeloid tumors, the gene encoding EVI2B may function as an oncogene in these tumor types. With expression in peripheral blood mononuclear cells, fibroblasts, bone marrow and EBV-transformed lymphoblastoid cell lines, EVI2B is implicated in leukemogenesis. Subcellular Location: Membrane. Tissue Specificity: Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines. Database links: Entrez Gene: 2124 Human Omim: 158381 Human SwissProt: P34910 Human Unigene: 5509 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
EVI2B是一种448个氨基酸蛋白，在黑素细胞和角质形成细胞的分化中起作用。在神经纤维蛋白基因内含子中，编码EVI2b的基因从端粒向着丝粒转录，这与神经纤维蛋白基因的转录方向相反。EVI2B是一个单通道跨膜蛋白，含有4个糖基化位点的细胞外结构域，一个N-末端信号肽，一个细胞质亲水域和一个疏水跨膜结构域。由于证据表明，编码小鼠同源基因的基因位于已被逆转录病毒诱导的髓样肿瘤中的病毒整合位点内，编码EVI2B的基因可能在这些肿瘤类型中起癌基因的作用。在外周血单个核细胞、成纤维细胞、骨髓和EBV转化的淋巴母细胞系中，EVI2B与白血病发生有关。