Acetoacetyl-CoA synthetase,脂肪酰辅酶A家族成员1抗体

产品编号bs-11383R
英文名称Acetoacetyl-CoA synthetase
中文名称脂肪酰辅酶A家族成员1抗体
别 名Acetoacetyl-CoA synthetase; ACSF1; AACS; Acyl-CoA synthetase family member 1; Protein sur-5 homolog; AACS_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量75kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
Acetoacetyl-CoA synthetase,脂肪酰辅酶A家族成员1抗体浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AACS (182-228aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Acetoacetyl-CoA synthetase,脂肪酰辅酶A家族成员1抗体PubMedPubMed
产品介绍background:
ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.

Function:
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development

Subcellular Location:
Cytoplasm, cytosol

Tissue Specificity:
Highly expressed in kidney, heart and brain, but low in liver.

Similarity:
Belongs to the ATP-dependent AMP-binding enzyme family.

Database links:
Entrez Gene: 65985 Human
Entrez Gene: 78894 Mouse
Entrez Gene: 65984 Rat
Omim: 614364 Human
SwissProt: Q86V21 Human
SwissProt: Q9D2R0 Mouse
SwissProt: Q9JMI1 Rat
Unigene: 656073 Human
Unigene: 431573 Mouse
Unigene: 9215 Rat

Acetoacetyl-CoA synthetase,脂肪酰辅酶A家族成员1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.