CCR4,细胞表面趋化因子受体4抗体

产品编号HZ-20787R
英文名称CCR4
中文名称细胞表面趋化因子受体4抗体
别 名CC chemokine receptor 4; chemokine (C-C motif) receptor 4; CC-CKR-4; CCR-4; CD194; CHEMOKINE CC4 RECEPTOR; CHEMR1; ChemR13; CKR4; CMKBR4; HGCN:14099; K5-5; LESTR; MGC151418; MGC88293; nocturnin, Sdf1r; chemokine C C motif receptor 4; ChemR13; CCR4_HUMAN; C-C chemokine receptor type 4; C-C CKR-4; CCR-4; CCR4; K5-5; CD 194; CD-194.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog,
CCR4,细胞表面趋化因子受体4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CCR4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CCR4,细胞表面趋化因子受体4抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Function:
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.

Post-translational modifications:
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.

CCR4,细胞表面趋化因子受体4抗体Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
1233

Database links:
Entrez Gene: 1233 Human
Entrez Gene: 12773 Mouse
GenBank: NP_005499.1 Human
Omim: 604836 Human
SwissProt: P51679 Human
SwissProt: P51680 Mouse
Unigene: 184926 Human
Unigene: 1337 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

趋化因子是当今细胞因子研究领域的热点之一,它参与多种免疫及炎症反应,在感染、肿瘤的生长与转移、组织修复及创伤愈合等病理生理过程中发挥重要作用.
C-C型趋化因子受体4(CCR4)在Th2细胞表面有大量表达.CCR4在肿瘤的生长与转移方面起到一定的作用。