FITC标记的驱动蛋白家族成员C1抗体
产品名称： FITC标记的驱动蛋白家族成员C1抗体
英文名称： Anti-KIFC1/FITC
产品编号： HZ-7805R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-KIFC1/FITC Conjugated antibody
FITC标记的驱动蛋白家族成员C1抗体
| 文名称 | Anti-KIFC1/FITC |
| 中文名称 | FITC标记的驱动蛋白家族成员C1抗体 |
| 别 名 | HSET KNSL2; KIF C1; KIFC 1; KIFC1; KIFC1_HUMAN; Kinesin family member C1; Kinesin like 2; Kinesin like protein 2; Kinesin like protein KIFC1; Kinesin related protein HSET; Kinesin-like protein 2; Kinesin-like protein KIFC1; Kinesin-related protein HSET; KNSL 2; KNSL2; Mitotic kinesin like protein 2; MKLP 2; MKLP2; RAB6 KIFL; Rabkinesin 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 74kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KIFC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIFC1 is a 673 amino acid protein that belongs to the kinesin-like family of proteins. KIFC1 localizes to the nucleus and contains a C-terminal kinesin-motor domain. Functioning as a minus-end directed microtubule-dependent motor, KIFC1 works together with NuMA and cytoplasmic Dynein to organize microtubule minus ends at spindle poles. HeLa cells deficient in KIFC1 exhibit multipolar mitotic spindles, suggesting that KIFC1 is essential for bipolar spindle formation. Function: Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Subunit: Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity). Subcellular Location: Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Early endosome. Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. Similarity: Belongs to the kinesin-like protein family. NCD subfamily. Contains 1 kinesin-motor domain. Database links: Entrez Gene: 3833 Human Omim: 603763 Human SwissProt: Q9BW19 Human Unigene: 436912 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
驱动蛋白构成一个大家族的微管依赖的运动蛋白，这是负责在细胞内的许多细胞器，囊泡和大分子复合物的分布。单独的驱动蛋白成员在细胞分裂、胞内运输和膜转运事件中起着关键的作用，包括胞吞作用和胞吞作用。KIFC1是一种673肽氨基酸，属于类驱动蛋白家族。KIFC1定位于细胞核，并含有C-末端驱动蛋白马达结构域。KIFC1作为负端定向微管依赖性的马达，与NUMA和cytoplasmic Dynein一起工作，在主轴极处组织微管负端。KIFC1中存在的HeLa细胞表现出多极有丝分裂纺锤体，提示KIFC1是双极纺锤体形成所必需的。