AFF4,淋巴细胞相关AF4样蛋白抗体

产品编号HZ-7886R
英文名称AFF4
中文名称淋巴细胞相关AF4样蛋白抗体
别 名Alf4; Laf4; MGC107469; AF4/FMR2 family member 4; AF5Q31; ALL1 fused gene from chromosome 5q31; HSPC092; Lymphoid nuclear protein related to AF4 like; Major CDK9 elongation factor associated protein; MCEF; RP23-226J16.7; AFF4_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
AFF4,淋巴细胞相关AF4样蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量127kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AFF4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AFF4,淋巴细胞相关AF4样蛋白抗体PubMedPubMed
产品介绍background:
May play a role in transcriptional regulation. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).

Function:
May play a role in transcriptional regulation.

Subunit:
Component of the cyclin-dependent kinase pair(CDK9/cyclin-T1) complex, also called positive transcriptionelongation factor b (P-TEFb).

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitously expressed. Strongly expressed inheart, placenta, skeletal muscle, pancreas and to a lower extent inbrain.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. [DISEASE] Note=A chromosomal aberration involving AFF4 is found inacute lymphoblastic leukemia (ALL). Insertion ins(5;11)(q31;q13q23)that forms a MLL-AFF4 fusion protein.

DISEASE:

Similarity:
Belongs to the AF4 family.

AFF4,淋巴细胞相关AF4样蛋白抗体Gene ID:
27125

Database links:
Entrez Gene: 27125 Human
Entrez Gene: 93736 Mouse
Entrez Gene: 303132 Rat
Omim: 604417 Human
SwissProt: Q9UHB7 Human
SwissProt: Q9ESC8 Mouse
Unigene: 519313 Human
Unigene: 395281 Mouse
Unigene: 17594 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.