FITC标记的TRMT12蛋白抗体
产品名称： FITC标记的TRMT12蛋白抗体
英文名称： Anti-TRMT12/FITC
产品编号： HZ-17144R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TRMT12/FITC Conjugated antibody
FITC标记的TRMT12蛋白抗体
| 英文名称 | Anti-TRMT12/FITC |
| 中文名称 | FITC标记的TRMT12蛋白抗体 |
| 别 名 | Alpha amino alpha carboxypropyl transferase TYW2; FLJ20772; Homolog of yeast tRNA methyltransferase; Radical S-adenosyl methionine and flavodoxin domain-containing protein 2; TRM 12; TRM12; TRMT 12; TRMT12; tRNA methyltransferase 12; tRNA methyltransferase 12 homolog; tRNA wybutosine-synthesizing protein 2 homolog; tRNA-yW-synthesizing protein 2; TYW2; TYW2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRMT12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Transfer RNA (tRNA) modifications help regulate the efficiency of mRNA translation by maintaining the correct reading frames. TRM12 (tRNA methyltransferase 12 homolog (S. cerevisiae)), also known as TYW2 (tRNA-yW-synthesizing protein 2) or TRMT12, is a 448 amino acid protein that belongs to the RNA methyltransferase trmD family and TYW2 subfamily. TRM12 is the human homolog of a yeast gene that is essential for the synthesis of yW (wybutosine), a guanosine that stabilizes codon-anticodon associations near the anticodon of phenylalanine tRNA during ribosomal decoding. The gene encoding TRRM12 maps to human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Similarity: Belongs to the RNA methyltransferase trmD family. TYW2 subfamily. Database links: Entrez Gene: 55039 Human Entrez Gene: 68260 Mouse Omim: 611244 Human SwissProt: Q53H54 Human SwissProt: Q8BG71 Mouse Unigene: 9925 Human Unigene: 278805 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转移RNA（TRNA）修饰有助于通过保持正确的阅读框来调节mRNA翻译的效率。TRM12(tRNA甲基转移酶12同源物(酿酒酵母))又称TYW2(tRNA-yW合成蛋白2)或TRMT12，是属于RNA甲基转移酶trmD家族和TYW2亚家族的448个氨基酸蛋白。TRM12是酵母基因的人类同源物，该基因对于合成yW(wybutosine)是必不可少的，yW(wybutosine)是一种鸟苷，在核糖体解码期间稳定苯丙氨酸tRNA反密码子附近的密码子-反密码子关联。编码TRRM12的基因定位于人类8号染色体，由近1.46亿个碱基对组成，编码800多个基因，与各种疾病和恶性肿瘤有关。精神分裂症、双相情感障碍、8三体、Pfeiffer综合征、先天性甲状腺功能减退、Waardenburg综合征和一些白血病和淋巴瘤被认为是由于肿瘤特异性基因缺陷而发生的。