FITC标记的磷酸化低密度脂蛋白受体相关蛋白1抗体
产品名称： FITC标记的磷酸化低密度脂蛋白受体相关蛋白1抗体
英文名称： Anti-phospho-LRP1(Ser4523)/FITC
产品编号： HZ-5409R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-LRP1(Ser4523)/FITC Conjugated antibody
FITC标记的磷酸化低密度脂蛋白受体相关蛋白1抗体
| 英文名称 | Anti-phospho-LRP1(Ser4523)/FITC |
| 中文名称 | FITC标记的磷酸化低密度脂蛋白受体相关蛋白1抗体 |
| 别 名 | A2MR; Alpha 2 macroglobulin receptor; alpha 2MR; APOER; Apolipoprotein E receptor; APR; CD 91; CD91; CD91 antigen; Low density lipoprotein receptor related protein 1; Low density lipoprotein related protein 1; LRP 1; LRP 515; LRP 85; LRP; LRP ICD; LRP1; LRP1 protein; LRP515. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 心血管 免疫学 神经生物学 信号转导 合成与降解 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 500kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human LRP1 around the phosphorylation site of Ser4523 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus. Subunit: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Interacts with bacterial exotoxins. Subcellular Location: Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit. Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit. Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Tissue Specificity: Most abundant in liver, brain and lung. Similarity: Belongs to the LDLR family. Contains 22 EGF-like domains. Contains 31 LDL-receptor class A domains. Contains 34 LDL-receptor class B repeats. Database links: Entrez Gene: 4041 Human Entrez Gene: 16973 Mouse Entrez Gene: 293649 Rat Omim: 603506 Human SwissProt: O75197 Human SwissProt: Q91VN0 Mouse Unigene: 6347 Human Unigene: 274581 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
低密度脂蛋白受体相关蛋白（也称为低密度LRP、LRP1、α2-巨球蛋白受体或载脂蛋白E受体）是一种参与胞吞作用和吞噬细胞凋亡的内吞受体。它是早期胚胎发育所必需的，参与细胞脂质稳态，并可能在APP代谢、激酶依赖的细胞内信号传导、神经元钙信号传导和神经传递中发挥作用。低密度LRP也参与了乳糜微粒残余物和活化的LRPAP1（α2-巨球蛋白）的血浆清除，参与了纤溶酶原激活物及其内源性配体复合物的局部代谢。低密度LPR被认为是宿主抗HIV的主要宿主之一。前体低密度LRP分子在翻译后裂解形成85 kDa膜跨越亚基（LRP85）和515 kDa的大胞外域（LRP515），其与LRP85保持非共价关联。卵裂后，胞内结构域（LPRICD）存在于细胞质和细胞核中。