FITC标记的磷酸化丝裂原活化蛋白激酶MAP4K4抗体
产品名称： FITC标记的磷酸化丝裂原活化蛋白激酶MAP4K4抗体
英文名称： Anti-phospho-MAP4K4(Ser631)/FITC
产品编号： HZ-5492R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-MAP4K4(Ser631)/FITC Conjugated antibody
FITC标记的磷酸化丝裂原活化蛋白激酶MAP4K4抗体
| 英文名称 | Anti-phospho-MAP4K4(Ser631)/FITC |
| 中文名称 | FITC标记的磷酸化丝裂原活化蛋白激酶MAP4K4抗体 |
| 别 名 | MAP4K4(phospho S631); p-MAP4K4(phospho S631); Hepatocyte progenitor kinase like/germinal center kinase like kinase; HGK; HPK/GCK like kinase; HPK/GCK like kinase HGK; KIAA0687; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; MEKKK4; Mitogen activated protein kinase kinase kinase kinase 4; Nck interacting kinase; NIK. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 142kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human MAP4K4 around the phosphorylation site of Ser631 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) belongs to the serine/threonine protein kinase family and specifically activates MAPK8/JNK. It may play a role in the response to environmental stress and is thought to function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF alpha signaling pathway. It interacts with the SH3 domain of the adapter protein Nck. MAP4K4-dependent signaling inhibits PPARG responsive gene expression, adipogenesis, and insulin stimulated glucose transport. Function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. Subunit: Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially). Subcellular Location: Cytoplasm. Tissue Specificity: Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain. Database links: Entrez Gene: 9448 Human Omim: 604666 Human SwissProt: O95819 Human Unigene: 431550 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MAP4K4（丝裂原活化蛋白激酶激酶激酶4）属于丝氨酸/苏氨酸蛋白激酶家族，特异性激活MAPK8/JNK。它可能在环境应激反应中起作用，并认为通过MAP3K7 MAP2K4-MAP2K7激酶级联作用，介导TNF-α信号通路。它与NCK结合蛋白的SH3结构域相互作用。MAP4K4依赖信号抑制pPARG应答基因表达、脂肪生成和胰岛素刺激的葡萄糖转运。