phospho-B MyB (Ser577),磷酸化转录因子MYB相关蛋白B抗体

产品编号HZ-12553R
英文名称phospho-B MyB (Ser577)
中文名称磷酸化转录因子MYB相关蛋白B抗体
别 名B MyB (phospho S577); p-B MyB (phospho S577); p-B MyB (phospho S581) (mouse);B-Myb; BMyB; MYB L2; Myb related protein B; Myb-like protein 2; Myb-related protein B; MybB; MYBB_HUMAN; MYBL 2; Mybl2; v myb avian myeloblastosis viral oncogene homolog like 2; v myb myeloblastosis viral oncogene homolog (avian) like 2; v myb myeloblastosis viral oncogene homolog like 2.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域肿瘤 细胞生物 信号转导 细胞周期蛋白 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Rabbit,
phospho-B MyB (Ser577),磷酸化转录因子MYB相关蛋白B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量79kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human B MyB around the phosphorylation site of Ser577 + Ser581
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-B MyB (Ser577),磷酸化转录因子MYB相关蛋白B抗体PubMedPubMed
产品介绍background:
Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in the regulation of cell survival, proliferation, and differentiation. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes.

Function:
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Subunit:
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.

Subcellular Location:
Nucleus.

Tissue Specificity:

Post-translational modifications:
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.

Similarity:
Contains 3 HTH myb-type DNA-binding domains.

Gene ID:
4605

phospho-B MyB (Ser577),磷酸化转录因子MYB相关蛋白B抗体Database links:
Entrez Gene: 4605 Human
Entrez Gene: 17865 Mouse
Entrez Gene: 296344 Rat
Omim: 601415 Human
SwissProt: P10244 Human
SwissProt: P48972 Mouse
Unigene: 179718 Human
Unigene: 4594 Mouse
Unigene: 20824 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.