FITC标记的泛素载体蛋白R2抗体
产品名称： FITC标记的泛素载体蛋白R2抗体
英文名称： Anti-CDC34B/FITC
产品编号： HZ-3813R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CDC34B/FITC Conjugated antibody
FITC标记的泛素载体蛋白R2抗体
| 英文名称 | Anti-CDC34B/FITC |
| 中文名称 | FITC标记的泛素载体蛋白R2抗体 |
| 别 名 | CDC34B; E2 CDC34B; UBE2R2; Ubiquitin carrier protein R2; Ubiquitin conjugating enzyme E2 CDC34B; Ubiquitin conjugating enzyme E2 R2; Ubiquitin conjugating enzyme E2R 2; Ubiquitin conjugating enzyme UBC3B; Ubiquitin protein ligase R2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDC34B(128-165aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: UBC3B is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. Subunit: When phosphorylated, interacts with beta-TrCP (BTRC). Similarity: Belongs to the ubiquitin-conjugating enzyme family. Database links: Entrez Gene: 54926 Human Entrez Gene: 67615 Mouse Entrez Gene: 299677 Rat Omim: 612506 Human SwissProt: Q712K3 Human SwissProt: Q6ZWZ2 Mouse Unigene: 643648 Human Unigene: 725177 Human Unigene: 389540 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
UBC3B是一种普遍存在的多效性的SR/THR蛋白激酶，参与细胞的生长和转化。该基因编码类似于E2泛素缀合酶UBC3/CDC34的蛋白质。研究表明，这种泛素缀合酶的CK2依赖磷酸化通过调节β-TrCP底物识别而发挥作用，并诱导其与β-TrCP的相互作用，增强β-连环蛋白降解。