FITC标记的胰辅脂酶抗体
产品名称： FITC标记的胰辅脂酶抗体
英文名称： Anti-CLPS/FITC
产品编号： HZ-10088R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CLPS/FITC Conjugated antibody
FITC标记的胰辅脂酶抗体
| 英文名称 | Anti-CLPS/FITC |
| 中文名称 | FITC标记的胰辅脂酶抗体 |
| 别 名 | Colipase; Colipase pancreatic; Pancreatic colipase preproprotein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 内分泌病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 10kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLPS |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Enterostatin has a biological activity as a satiety signal. Subunit: Forms a 1:1 stoichiometric complex with pancreatic lipase. Subcellular Location: Secreted. Tissue Specificity: Expressed by the pancreas. Similarity: Belongs to the colipase family. Database links: Entrez Gene: 1208 Human Omim: 120105 Human SwissProt: P04118 Human Unigene: 1340 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是胰脂肪酶所需的辅因子，用于有效的膳食脂肪水解。它与脂肪酶的C端、非催化结构域结合，从而稳定了活性构象，并显著增加了整个疏水结合位点。该基因产物允许脂肪酶非共价地锚定在脂质胶束的表面，抵消肠胆汁盐的不稳定影响。该辅因子仅在胰腺腺泡细胞中表达，提示组织特异性元件对表达的调节。已经发现了三个编码不同亚型的转录本变体。[ RefSeq，2011月11日]