FITC标记的1号染色体开放阅读框55抗体
产品名称： FITC标记的1号染色体开放阅读框55抗体
英文名称： Anti-C1orf55/FITC
产品编号： HZ-15071R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C1orf55/FITC Conjugated antibody
FITC标记的1号染色体开放阅读框55抗体
| 英文名称 | Anti-C1orf55/FITC |
| 中文名称 | FITC标记的1号染色体开放阅读框55抗体 |
| 别 名 | C1orf55; CA055_HUMAN; Chromosome 1 open reading frame 55; dJ671D7.1; FLJ35382; Hypothetical protein LOC163859; RP4 671D7.1; UPF0667 protein C1orf55. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C1orf55 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Belonging to the UPF0667 family, C1orf55 is a 451 amino acid protein that is phosphorylated upon DNA damage, likely by Atm or ATR. There are three different isoforms of C1orf55 that are produced as a result of alternative splicing events. The gene encoding C1orf55 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Similarity: Belongs to the SDE2 family. Database links: UniProtKB/Swiss-Prot: Q6IQ49.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
属于UPF0667家族，C1orf55是一个451氨基酸的蛋白质，在DNA损伤时被磷酸化，可能是由Atm或ATR。有三种不同的C1OF55异构体，它们是作为选择性剪接事件的结果而产生的。编码C1orf55的基因定位于人类染色体1，最大的人类染色体跨越约2.6亿个碱基对，占人类基因组的8%。在1号染色体上有大约3000个基因，并且考虑到大量的基因，也有大量的与染色体1相关的疾病。值得注意的是，罕见的衰老性疾病Hutchinson Gilford早老症与LMNA基因编码，lamin A.基因在缺陷时编码，LMNA基因产物可在细胞核中积聚并引起特征性核泡。迅速增强衰老的机制尚不清楚，是一个继续探索的话题。MutyH基因位于1号染色体上，是家族性腺瘤性息肉病的部分原因。Stutkle综合征、帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。