AKR1B1,醛糖还原酶抗体

产品编号HZ-2405R
英文名称AKR1B1
中文名称醛糖还原酶抗体
别 名MGC134297; ADR; aldehyde reductase 1; Aldehyde reductase; Aldose reductase; aldr 1; ALDR1; low Km aldose reductase.
规格价格0.1ml 0.2ml
说 明 书0.1ml 0.2ml
研究领域心血管 免疫学 激酶和磷酸酶 糖尿病
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Rabbit,
AKR1B1,醛糖还原酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AKR1B1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AKR1B1,醛糖还原酶抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Subunit:
Monomer.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.

Similarity:
Belongs to the aldo/keto reductase family.

Gene ID:
231

AKR1B1,醛糖还原酶抗体Database links:
Entrez Gene: 231 Human
Entrez Gene: 11677 Mouse
Entrez Gene: 396816 Pig
Entrez Gene: 100009122 Rabbit
Entrez Gene: 24192 Rat
Omim: 103880 Human
SwissProt: P15121 Human
SwissProt: P45376 Mouse
SwissProt: P80276 Pig
SwissProt: P15122 Rabbit
SwissProt: P07943 Rat
Unigene: 521212 Human
Unigene: 451 Mouse
Unigene: 485031 Mouse
Unigene: 107801 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

醛糖还原酶是多元醇通路的关键限速酶,当血糖在正常生理水平时，它并不激活，它对葡萄糖的亲和力较低。在高血糖状况下（如糖尿病），磷酸己糖激酶饱和， 醛糖还原酶激活，促使体内的葡萄糖转化为山梨醇。然而，山梨醇脱氢酶（sorbitol dehydrogenase，SDH）的活力并未相应地成比例增加，山梨醇转化为果糖的效率没有提高,山梨醇本身由于极性强不易通过细胞膜，在细胞内会形成蓄积，使细胞膜的通透性发生改变，并使细胞中Na+-K+-ATP酶活性下降，造成肌醇丧失，导致细胞代谢与功能的损害。
因眼睛和神经细胞等组织内醛糖还原酶的含量较高，糖尿病病人体内高血糖的环境使这一通路很容易被打开，造成对相关组织的病理损害，如糖尿病、白内障、神经病变、肾脏病变、视网膜病变、动脉粥样硬化等糖尿病并发症DCC的发生。