FITC标记的胰岛素样生长因子1受体相互作用蛋白1抗体
产品名称： FITC标记的胰岛素样生长因子1受体相互作用蛋白1抗体
英文名称： Anti-GIPC1/FITC
产品编号： HZ12304R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GIPC1/FITC Conjugated antibody
FITC标记的胰岛素样生长因子1受体相互作用蛋白1抗体
| 英文名称 | Anti-GIPC1/FITC |
| 中文名称 | FITC标记的胰岛素样生长因子1受体相互作用蛋白1抗体 |
| 别 名 | C19ORF3; Chromosome 19 open reading frame 3; GIPC; GLUT1 C terminal binding protein; GLUT1CBP; IGF 1 receptor interacting protein 1; IIP 1; IIP1; NIP; PDZ domain-containing protein GIPC1; Regulator of G protein signalling 19 interacting protein 1; RGS19 interacting protein 1; RGS19IP1; SEMCAP; SYNECTIIN; Tax interaction protein 2; TIP 2; GIPC1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul a |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GIPC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: GIPC, for GAIP interacting protein at the C terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for G(a i) subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain. Function: GIPC1 is a hydrophilic protein that contains 333 amino acids, including multiple phosphorylation sites and an 80 to 100 amino acid PDZ domain. PDZ domain-containing proteins typically recognize C terminal amino acids and are involved in protein network signaling. GIPC1 may be involved in G protein-linked signaling. Subunit: Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain. Subcellular Location: Cell Membrane, peripheral membrane protein and Cytoplasmic. Tissue Specificity: Widely expressed. Similarity: Belongs to the GIPC family. Contains 1 PDZ (DHR) domain. Database links: UniProtKB/Swiss-Prot: O14908.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GIPC，用于在C末端的GAIP相互作用蛋白（也称为SEMCAP-1或synectin），是一个PDZ结构域，包含与RGS-GAIP相互作用的蛋白质，RGS-GAIP是G(a i)亚基的GTP酶激活蛋白（GAP）。GIPC也被鉴定为TIP-2，一种与病毒癌蛋白TAX相互作用的蛋白，通过与各种转录因子的相互作用，TAX反式激活病毒和细胞启动子。含PDZ结构域的蛋白主要定位于上皮细胞和神经元的细胞-细胞连接，它们协调多蛋白复合物的组装。GIPC特异定位于质膜附近的小泡簇，并参与G蛋白偶联信号通路，参与调节包膜囊泡运输。GIPC还与膜结合信号素F(M-SemF)有关，M-SemF参与神经元轴突的生长，它似乎调节着M-SemF在大脑中的亚细胞分布。