Calretinin,钙结合蛋白抗体

产品编号HZ-0062R
英文名称Calretinin
中文名称钙结合蛋白抗体
别 名29 kDa calbindin; CAB 29; CAB29; CAL 2; CAL2; CALB 2; CALB2; Calbindin 2 29kDa; Calbindin 2; Calbindin D29K; Calbindin2; CR; CALB2_HUMAN; Calretinin.
说 明 书0.1ml 0.2ml
研究领域神经生物学 结合蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
Calretinin,钙结合蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Calretinin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Calretinin,钙结合蛋白抗体PubMedPubMed
产品介绍background:
Calretinin is a calcium-binding protein which is abundant in auditory neurons. It belongs to the calbindin family. Calbindin 2 (calretinin), closely related to calbindin 1, is an intracellular calcium-binding protein belonging to the troponin C superfamily. Calbindin 1 is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin 1 and calbindin2 is poorly understood. The sequence of the calbindin 2 cDNA reveals an open reading frame of 271 codons coding for a protein of 31,520 Da, and shares 58% identical residues with human calbindin1.

Function:
Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Tissue Specificity:
Brain.

Similarity:
Belongs to the calbindin family.
Contains 6 EF-hand domains.

Gene ID:
794

Calretinin,钙结合蛋白抗体Database links:
Entrez Gene: 396255 Chicken
Entrez Gene: 794 Human
Entrez Gene: 12308 Mouse
Entrez Gene: 117059 Rat
Entrez Gene: 393684 Zebrafish
Omim: 114051 Human
SwissProt: P07090 Chicken
SwissProt: P22676 Human
SwissProt: Q08331 Mouse
SwissProt: P47728 Rat
Unigene: 106857 Human
Unigene: 2755 Mouse
Unigene: 10321 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

钙结合蛋白(Calretinin,CR)主要存在于神经组织中，近10%的腺癌可以表达此蛋白的局部染色阳性，而绝大多数的间皮瘤为阳性表达，因此它是诊断间皮瘤的一个有用的标记物 。
钙结合蛋白是平滑肌和非肌性调控蛋白。它可以与肌动蛋白、肌球蛋白、原肌球蛋白和钙调素相互作用。