FITC标记的酪氨酸激酶受体C抗体
产品名称： FITC标记的酪氨酸激酶受体C抗体
英文名称： Anti-TrkC/FITC
产品编号： HZ-0176R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TrkC/FITC Conjugated antibody
FITC标记的酪氨酸激酶受体C抗体
| 英文名称 | Anti-TrkC/FITC |
| 中文名称 | FITC标记的酪氨酸激酶受体C抗体 |
| 别 名 | EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETV6 NTRK3 fusion; GP145 TrkC; gp145(trkC); GP145TrkC; Neurotrophic tyrosine kinase receptor type 3; Neurotrophin 3 receptor; NT 3 growth factor receptor; NT 3 growth factor receptor precursor; NT 3 receptor; NTRK3; NTRK3_HUMAN; OTTHUMP00000192915; TRK C; TrkC tyrosine kinase; Tyrosine kinase receptor C. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 发育生物学 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 91kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TrkC |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor, gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex. Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain. Post-translational modifications: Ligand-mediated auto-phosphorylation. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain. Database links: Entrez Gene: 4916 Human Entrez Gene: 18213 Mouse Entrez Gene: 29613 Rat Omim: 191316 Human SwissProt: Q16288 Human SwissProt: Q6VNS1 Mouse SwissProt: Q03351 Rat Unigene: 410969 Human Unigene: 706364 Human Unigene: 33496 Mouse Unigene: 421361 Mouse Unigene: 9963 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
神经生长因子受体Trk家族包括Trk A(也称为Trk A gp140)、Trk B和Trk C。该基因家族的原型成员Trk A编码140kDa细胞表面受体gp140，其在体内的表达仅限于感觉脊髓和颅神经细胞。神经根起源于神经节。神经生长因子（NGF）刺激神经细胞系和胚胎背根神经节中Trk gp 140的酪氨酸磷酸化。通过比较，BDNF和在较小程度上，NT-3，但不是NGF，可诱导Trk B GP 145的酪氨酸磷酸化。Trk C是Trk受体家族的第三个成员，它含有一个140kDa的蛋白质，Trk C gp140，它优先在脑组织中表达，主要作为NT-3的受体。但是需要高效的信令。NGFR p175加速Trk活化，并可能招募下游的Dffffer-Mangin分子到配体结合的受体复合物。