FITC标记的NOMO蛋白抗体
产品名称： FITC标记的NOMO蛋白抗体
英文名称： Anti-NOMO1/FITC
产品编号： HZ-11595R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NOMO1/FITC Conjugated antibody
FITC标记的NOMO蛋白抗体
| 产品编号 | bs-11595R-FITC |
| 英文名称 | Anti-NOMO1/FITC |
| 中文名称 | FITC标记的NOMO蛋白抗体 |
| 别 名 | Nodal modulator 1; NOMO 1; Nomo; NOMO1; NOMO1_HUMAN; PM5; pM5 protein; pM5 protein telomeric copy; NOMO1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 信号转导 生长因子和激素 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 131kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NOMO1 (701-800aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Three highly similar proteins termed NOMO1, NOMO2 and NOMO3, are encoded by a gene mapping to a region of duplication on the p arm of human chromosome 16. All three NOMO proteins share similar functions and have been difficult to characterize individually. NOMO1 (Nodal modulator 1), also known as PM5, is a 1,222 amino acid highly conserved single-pass type I membrane protein expressed in colon tumor tissue and normal colonic mucosa. NOMO proteins are novel antagonists of Nodal signaling which interact with Nicalin to form a Nicalin-NOMO complex, and are rapidly degraded or stabilized by Nicalin. NOMO proteins were once considered candidates for the development of pseudoxanthoma elasticum (PXE), a heritable disorder of connective tissue, as the NOMO genes are located in close proximity to the gene responsible for PXE development (MRP6). Function: May antagonize Nodal signaling. Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Expressed in colon tumor tissue and in adjacent normal colonic mucosa. Database links: UniProtKB/Swiss-Prot: Q15155.5 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
三个高度相似的蛋白质被称为NOMO 1、NOMO2和NOMO3，通过基因映射编码到人类染色体16的P臂上的重复区域。所有三个NOMO蛋白具有相似的功能，并且难以单独表征。NOMO1（节调节剂1），又称PM5，是结肠肿瘤组织和正常结肠粘膜中表达的1222氨基酸高度保守的单程I型膜蛋白。NOMO蛋白是Nealin信号的新拮抗剂，与尼卡林相互作用，形成尼卡林-诺莫复合物，并被尼卡林迅速降解或稳定。NOMO蛋白曾经被认为是发展为假结缔组织瘤（PXE）的候选，是一种遗传性结缔组织疾病，因为NOMO基因位于与PXE发育相关的基因（MRP6）的附近。