FITC标记的信号感应增殖相关蛋白1抗体
产品名称： FITC标记的信号感应增殖相关蛋白1抗体
英文名称： Anti-SPA-1/FITC
产品编号： HZ-1602R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-SPA-1/FITC Conjugated antibody
FITC标记的信号感应增殖相关蛋白1抗体
| 英文名称 | Anti-SPA-1/FITC |
| 中文名称 | FITC标记的信号感应增殖相关蛋白1抗体 |
| 别 名 | GTPase activating protein Spa 1; GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; p130 SPA1; Signal induced proliferation associated 1; Signal induced proliferation associated gene 1; Signal induced proliferation associated protein 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; SIPA 1; Sipa-1; Sipa1; SIPA1_HUMAN; Spa1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 染色质和核信号 信号转导 干细胞 细胞凋亡 细胞周期蛋白 细胞表面分子 表观遗传学 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 112kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPA-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. Subcellular Location: Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region. Tissue Specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. Similarity: Contains 1 PDZ (DHR) domain. Contains 1 Rap-GAP domain. Database links: Entrez Gene: 6494 Human Entrez Gene: 20469 Mouse Omim: 602180 Human SwissProt: Q96FS4 Human SwissProt: P46062 Mouse Unigene: 530477 Human Unigene: 3072 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SPA 1是重要的Rap1GTP酶激活蛋白.SPA-1参与细胞的程序性死亡，在很多恶性肿瘤的发生、发展中起到一定的作用。 |
该基因的产物是有丝分裂原诱导的GTP酶激活蛋白（GAP）。它对RAS相关调节蛋白RAP1和RAP2具有特异性的间隙活性，但对RAN或其它小GTP酶不具有特异的间隙活性。当异常或过早表达时，这种蛋白质也可能阻碍丝裂原诱导的细胞周期进程。它定位于核周区。编码相同的异构体的两个交替剪接变异体的特征是迄今为止。