FITC标记的迟钝蛋白家族2抗体
产品名称： FITC标记的迟钝蛋白家族2抗体
英文名称： Anti-DOPEY2/FITC
产品编号： HZ-14410R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DOPEY2/FITC Conjugated antibody
FITC标记的迟钝蛋白家族2抗体
| 英文名称 | Anti-DOPEY2/FITC |
| 中文名称 | FITC标记的迟钝蛋白家族2抗体 |
| 别 名 | 21orf5; Dopey-2; C21orf5; DOP2_HUMAN; Dopey family member 2; DOPEY2; homolog of yeast DOP1; Protein dopey-2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 258kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DOPEY2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dopey-2 is a 2,298 amino acid protein that is ubiquitously expressed with high levels found in the developing central nervous system where it is thought to play a role in protein trafficking between early endosomes and the late Golgi. Multiple isoforms of Dopey-2 exist due to alternative splicing events. The gene encoding Dopey-2 maps to human chromosome 21 and may be involved in the pathogenesis of Down syndrome. The smallest of the human chromosomes, chromosome 21 comprises about 1.5% of the human genome and contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer's disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukemias. Function: May be involved in protein traffic between late Golgi and early endosomes. Tissue Specificity: Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients. DISEASE: Abundantly expressed in developing central nervous system, with highest levels in cerebellum and lowest in telencephalon. Similarity: Belongs to the dopey family. Database links: Entrez Gene: 9980 Human Entrez Gene: 70028 Mouse Omim: 604803 Human SwissProt: Q9Y3R5 Human SwissProt: Q3UHQ6 Mouse Unigene: 204575 Human Unigene: 23230 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Dopey-2是一种2298氨基酸的蛋白质，在发育中的中枢神经系统中广泛表达，被认为在早期内胚体和晚期高尔基体之间的蛋白运输中起作用。由于替代剪接事件，存在多个异构体的-2 -2。编码DOXY-2的基因映射到人类21号染色体，可能参与唐氏综合征的发病机制。21号染色体是人类染色体中最小的一条，约占人类基因组的1.5%，包含近300个基因和4700万个碱基对。唐氏综合征，又称21三体，是最常见的与21号染色体相关的疾病。阿尔茨海默病、Jever和Lange Nielsen综合征和肌萎缩侧索硬化也与第21号染色体有关。在某些白血病中，染色体易位发生在21号染色体和8号染色体之间，以及染色体21和12之间。