FITC标记的大脑富含鸟苷酸激酶相关蛋白抗体
产品名称： FITC标记的大脑富含鸟苷酸激酶相关蛋白抗体
英文名称： Anti-BEGAIN/FITC
产品编号： HZ-11335R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-BEGAIN/FITC Conjugated antibody
FITC标记的大脑富含鸟苷酸激酶相关蛋白抗体
| 产品编号 | bs-11335R-FITC |
| 英文名称 | Anti-BEGAIN/FITC |
| 中文名称 | FITC标记的大脑富含鸟苷酸激酶相关蛋白抗体 |
| 别 名 | BEGAIN; BEGIN; Brain enriched guanylate kinase associated protein; Brain-enriched guanylate kinase-associated homolog (rat); KIAA1446; SAP90/PSD95 Associated Proteins; SAPAP; BEGIN_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BEGAIN |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: BEGAIN is a 593 amino acid protein that localizes to cytoplasm and membrane. BEGAIN interacts with PSD-95 and SAPAP1 and forms a ternary complex and may sustain the structure of the postsynaptic density (PSD). BEGAIN is a novel PSD component associated with the core complex of PSD-95 and SAPAP. Because BEGAIN and SAPAP interact with the same region of PSD-95, BEGAIN and SAPAP may compete for the binding to PSD-95 and cannot interact with PSD-95 simultaneously. The C-terminal region of BEGAIN is involved in the interaction with PSD-95 whereas the N-terminal region has a coiled-coil structure that may interact with other molecules. BEGAIN is specifically expressed in brain and enriched in the PSD fraction. BEGAIN is also expressed in neurons and enriched at synaptic junctions, and is likely involved in the organization of synaptic junction components. Function: Brain-enriched guanylate kinase-associated protein (BEGAIN) interacts with postsynaptic density (PSD)-95/synapse-associated protein (SAP) 90. BEGAIN has been detected in nuclei and at synapses in neurons. Subunit: Interacts with DLG4 and DLGAP1 and forms a ternary complex (By similarity). Subcellular Location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Database links: Entrez Gene: 57596 Human Entrez Gene: 380785 Mouse Entrez Gene: 79146 Rat Entrez Gene: 443287 Sheep SwissProt: Q9BUH8 Human SwissProt: Q68EF6 Mouse SwissProt: O88881 Rat SwissProt: Q6R6L0-4 Sheep Unigene: 211751 Human Unigene: 342085 Mouse Unigene: 30036 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
初生蛋白是一种定位于细胞质和膜的593氨基酸蛋白。开始与PSD-95和SAPAP1相互作用，并形成三元复合物，并可维持突触后密度（PSD）的结构。PaGeAN是一种新的PSD组件，它与PSD95和SAPAP的核心复合物相关联。因为BeaGeN和SAPAP与PSD-95的同一区域交互，所以BeaGeN和SAPAP可以竞争绑定到PSD-95，并且不能同时与PSD95交互。BEGAIN的C-末端区域参与了与PSD-95的相互作用，而N-末端区域具有与其他分子相互作用的卷曲螺旋结构。BeGeAN在脑中特异表达，并富含PSD分数。初生蛋白也在神经元中表达，并在突触连接处富集，并且可能参与突触连接组分的组织。