FITC标记的转铁蛋白受体抗体
产品名称： FITC标记的转铁蛋白受体抗体
英文名称： Anti-Transferrin receptor/CD71/FITC
产品编号： HZ-1782R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Transferrin receptor/CD71/FITC Conjugated antibody
FITC标记的转铁蛋白受体抗体
| 英文名称Anti-Transferrin receptor/CD71/FITC中文名称FITC标记的转铁蛋白受体抗体别 名CD 71; CD71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TFRC; TR; Transferrin receptor (p90 CD71); Transferrin Receptor Protein 1; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; Transferrin receptor protein 1, serum form; TRFR. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域肿瘤 心血管 细胞生物 免疫学 神经生物学 干细胞 糖尿病 细胞表面分子 细胞类型标志物 淋巴细胞 t-淋巴细胞 b-淋巴细胞 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 产品应用Flow-Cyt=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量74/85kDa细胞定位细胞膜 性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human CD71亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro. Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferring for an overlapping C-terminal binding site. Subunit: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Transferrin receptor protein 1, serum form: Secreted Post-translational modifications: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. Similarity: Belongs to the peptidase M28 family. M28B subfamily. Contains 1 PA (protease associated) domain. Database links: Entrez Gene: 7037 Human Entrez Gene: 22042 Mouse Entrez Gene: 64678 Rat Omim: 190010 Human SwissProt: P02786 Human SwissProt: Q62351 Mouse SwissProt: Q99376 Rat Unigene: 529618 Human Unigene: 28683 Mouse Unigene: 98672 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转铁蛋白及转铁蛋白受体(TfnrR)是机体铁代谢中的重要因子，铁是细胞生长增殖、代谢的必需元素,转铁蛋白受体(TfR)介导的胞吞作用是细胞摄取铁的主要途径。肿瘤细胞因增殖生长旺盛,对铁的需求高,所以肿瘤细胞有比正常细胞更多的转铁蛋白受体的表达。 |
|
细胞对铁的摄取是通过受体介导配体转铁蛋白受体内吞为特异性内体而发生的。内体酸化导致铁释放。然后，载脂蛋白受体复合物再循环到细胞表面，返回中性pH，并伴随载脂蛋白对其受体亲和力的丧失。转铁蛋白受体对于红细胞和神经系统的发育是必要的（通过相似性）。用于研究造血和肿瘤细胞群体和代谢活动的研究。第二配体，即遗传性血色素沉着症蛋白HFE，与转铁蛋白竞争结合以获得重叠的C端结合位点。该抗原存在于大多数分裂细胞上，包括体内正常循环的造血祖细胞、体外有丝分裂刺激细胞、一些原发肿瘤细胞和体外大多数增殖细胞。