FITC标记的JNK/ SAPK抑制激酶抗体
产品名称： FITC标记的JNK/ SAPK抑制激酶抗体
英文名称： Anti-JIK/TAOK3/FITC
产品编号： HZ-17202R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-JIK/TAOK3/FITC Conjugated antibody
FITC标记的JNK/ SAPK抑制激酶抗体
| 英文名称 | Anti-JIK/TAOK3/FITC |
| 中文名称 | FITC标记的JNK/ SAPK抑制激酶抗体 |
| 别 名 | CTCL tumor antigen HD CL 09; CTCL-associated antigen HD-CL-09; Cutaneous T cell lymphoma tumor antigen HD CL 09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell derived protein kinase; Dendritic cell-derived protein kinase; DKFZp666H245; DPK; FLJ31808; hKFC A; hKFC-A; JIK; JNK/SAPK inhibitory kinase; JNK/SAPK-inhibitory kinase; Jun kinase inhibitory kinase; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; MAP3K18; Serine kinase; Serine/threonine-protein kinase TAO3; STE20 like kinase; TAO kinase 3; TAOK3; TAOK3_HUMAN; Thousand and one amino acid protein 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 激酶和磷酸酶 淋巴细胞 t-淋巴细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 105kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human JIK |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: JNK/SAPK-inhibitory kinase (JIK) is a serine/threonine kinase that belongs to the STE20 kinase family. The kinase domain of JIK is similar to the GCK-like subfamily of STE20 kinases, while its non-catalytic domain is similar to a Caenorhabditis elegans putative serine/threonine kinase, SULU. JIK inhibits c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), which is activated by many types of cellular stresses and extracellular signals. JNK/SAPK regulates cell survival, apoptosis and proliferation in mouse development. JIK is negatively regulated by epidermal growth factor (EGF) and tyrosine kinase receptors. In unstimulated human T cells, JIK is cytoplasmic, whereas in the continuously dividing human T cells of Jurkat lymphoma, JIK is nuclear. Function: Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK. Subcellular Location: Cytoplasm. Cell membrane. Also localized to the peripheral cell membrane. Tissue Specificity: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. Post-translational modifications: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 51347 Human Entrez Gene: 330177 Mouse Entrez Gene: 100174000 Orangutan Entrez Gene: 304530 Rat Entrez Gene: 446778 Xenopus laevis SwissProt: Q9H2K8 Human SwissProt: Q9HC79 Human SwissProt: Q8BYC6 Mouse SwissProt: Q5R4F3 Orangutan SwissProt: Q53UA7 Rat SwissProt: Q6DD27 Xenopus laevis Unigene: 644420 Human Unigene: 24343 Mouse Unigene: 248296 Mouse Unigene: 162145 Rat Unigene: 27040 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
JNK/SAPK抑制激酶（JIK）是一种丝氨酸/苏氨酸激酶，属于St20激酶家族。JIK的激酶结构域类似于STE20激酶的GCK样亚家族，而非催化结构域类似于秀丽隐杆线虫推测的丝氨酸/苏氨酸激酶SULU。JIK抑制c-Jun NH2-末端激酶/应激激活蛋白激酶(JNK/SAPK)，其被多种类型的细胞应激和细胞外信号激活。JNK/SAPK调节小鼠发育中的细胞存活、凋亡和增殖。JIK受表皮生长因子（EGF）和酪氨酸激酶受体的负调控。在未经刺激的人T细胞中，JIK是胞浆，而在Jurkat淋巴瘤持续分裂的人T细胞中，JIK是核。