FITC标记的鸟苷酸环化酶激活蛋白2抗体
产品名称： FITC标记的鸟苷酸环化酶激活蛋白2抗体
英文名称： Anti-GCAP2/FITC
产品编号： HZ-13307R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GCAP2/FITC Conjugated antibody
FITC标记的鸟苷酸环化酶激活蛋白2抗体
| 英文名称 | Anti-GCAP2/FITC |
| 中文名称 | FITC标记的鸟苷酸环化酶激活蛋白2抗体 |
| 别 名 | GCAP 2; Guanylate Cyclase Activating Protein Photoreceptor 2; Guanylate Cyclase Activator 1B; Guanylin 2; Guanylyl cyclase-activating protein 2; GUC1B_HUMAN; GUCA 2; GUCA1B. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 结合蛋白 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GCAP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event. The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1. Function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Subcellular Location: Cell membrane. Membranes of outer segment. Tissue Specificity: Retina. Cones and rod. Similarity: Contains 4 EF-hand domains. Database links: UniProtKB/Swiss-Prot: Q9UMX6.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
钙对鸟苷酸环化酶（GC）的细胞内刺激是通过鸟苷酸环化酶激活蛋白（GCAP1）介导的，而钙是光暴露后杆状光感受器暗状态恢复的关键事件。GCAPS是属于钙调素超家族的钙结合蛋白。GCAP1是一种刺激光感受器中cGMP合成的钙结合蛋白。GCAP1存在于光传导发生的杆和锥光感受器外段。与钙调素超家族的其他钙结合蛋白相比，GCAP1的无钙形式刺激效应酶。通过对人和小鼠GCAP cDNA的分子克隆，发现哺乳动物GCAP cDNA相似度超过90％，由201-205个氨基酸组成，并含有三个相同保守的钙结合位点。相关蛋白GCAP2仅在视网膜中检测到，并且是由基因复制事件引起的。编码GCAP1和GCAP2的基因编码到人类染色体621.1。