神经毒性PCR芯片可用于研究参与药物或者化学诱导得神经毒性反应的84个关键基因的表达。使药物的毒性最小化，是药物上市前最大的障碍。神经毒性是常见而且棘手的副反应，所以使得中枢神经和外周神经是毒理学的重要研究对象。可量化的基因表达的变化可以使我们在表型变化之前尽早发现神经毒性，并且了解其深层的机制。该芯片包含多种神经毒性反应的分子标志物，包括外周神经，中枢运动神经，发育神经毒性以及帕金森氏病。通过分析这些基因的表达，具有神经毒性的药物可以在研究的早期就排除在外，减小研究的时间和成本。利用实时定量PCR，研究者可以方便并且可信地对与神经毒性相关的基因进行同时检测。
Up-Regulated: Apoptosis: ABL1, BAG4, BIK, CASP7, CDKN1A, CIDEA, CIDEB, CRADD, DAPK1, FAS, FASLG, GCH1, SOD2, TNFRSF10B, TNFRSF11B, TP53, TRAF4, YWHAE. Development: CASP7, DRP2, EREG, HEPH, IL10, MMP9, PLP1, SOD2, TP53, YWHAE. Metabolism (Regulation & Mechanism): ABL1, ARG2, ARRB1, ATF4, CDKN1A, CIDEA, DDIT3, DYNLL1, EREG, GAL, GUCY1A3, HSP90AA1, IL10, NFKB1, POU1F1, RASD1, SLC16A3, SOD2, TNFRSF10B, TP53, TRAF2, USP7, YWHAE. Nitric Oxide Response: ARG1, ARG2, DYNLL1, GUCY1A3, NOS1AP, NOSIP, NOSTRIN, RASD1, SLC16A3. Signal Transduction: ABL1, ARRB1, CD8B, CDKN1A, CIDEA, CIDEB, DAPK1, DDIT3, FASLG, GPR37, GUCY1A3, HSPA5, IL10, RASD1, TNFRSF10B, TP53, TRAF2, YWHAE. Ion Transport: CAMK2D, CLCN5, CLCNKA, HEPH, SFXN5, TRPM1, TRPM4. Other: ANGPTL4, PAPPA, PDIA4. Down-Regulated: Apoptosis: LTA, NOL3, TNFRSF25, XIAP. Development: BDNF, KIT, LEFTY2, LTA, NOTCH4, SEMA3B. Metabolism (Regulation & Mechanism): BDNF, CAMK2A, CCND1, CDO1, DRD2, EIF2AK3, GALC, GRIN1, GSR, HTR1A, KIT, LDHA, NOTCH4, PRIM2, TPH1, TXNIP, TYRP1. Signal Transduction: BIRC2, CCND1, DRD2, EIF2AK3, GSN, HTR1A, KIT, TACR1. Ion Transport: DRD2, GRIN1. Other: COL12A1, EGLN3, HTR3A, NUP50.