CHRNA5,烟碱型乙酰胆碱受体α5抗体

产品编号HZ-19240R
英文名称CHRNA5
中文名称烟碱型乙酰胆碱受体α5抗体
别 名Acetylcholine receptor nicotinic alpha 5 (neuronal); ACHA5_HUMAN; Cholinergic receptor neuronal nicotinic alpha polypeptide 5; Cholinergic receptor nicotinic alpha 5; Cholinergic receptor nicotinic alpha polypeptide 5; CHRNA 5; CHRNA5; LNCR2; NACHRA 5; NACHRA5; Neuronal acetylcholine receptor subunit alpha 5; Neuronal acetylcholine receptor subunit alpha-5; Neuronal nicotinic acetylcholine receptor alpha 5 subunit; Neuronal nicotinic acetylcholine receptor, alpha5 subunit; OTTHUMP00000185019.
说 明 书0.1ml 0.2ml
研究领域免疫学 神经生物学 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Chicken, Pig, Cow, Horse, Monkey, Chimpanzee,
CHRNA5,烟碱型乙酰胆碱受体α5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CHRNA5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CHRNA5,烟碱型乙酰胆碱受体α5抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:
Cell junction > synapse > postsynaptic cell membrane. Cell membrane.

Tissue Specificity:
High expression level is found in brain, testis, liver and kidney. Weak expression in spleen, leukocytes, small intestine and colon

Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.

Database links:
Entrez Gene: 386577 Chicken
Entrez Gene: 619369 Chimpanzee
Entrez Gene: 282177 Cow
Entrez Gene: 1138 Human
Omim: 118505 Human
SwissProt: P26152 Chicken
SwissProt: Q5IS51 Chimpanzee
SwissProt: Q8SPU7 Cow
SwissProt: P30532 Human
Unigene: 1614 Human
Unigene: 719767 Human

CHRNA5,烟碱型乙酰胆碱受体α5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.