FAP1,Fas相关磷酸酶1抗体

产品编号HZ-5760R
英文名称FAP1
中文名称Fas相关磷酸酶1抗体
别 名APO1/CD95 (Fas) associated phosphatase; Fas associated phosphatase 1; Protein tyrosine phosphatase non receptor type 13; PTP BAS; PTP BL; DKFZp686J1497; FAP 1; FAP-1; FAP1; Fas associated protein tyrosine phosphatase 1; Fas-associated protein-tyrosine phosphatase 1; HGNC:9646; hPTPE1; PNP 1; PNP1; Protein tyrosine phosphatase 1 Fas associated; protein tyrosine phosphatase 1E; Protein tyrosine phosphatase nonreceptor type 13; Protein tyrosine phosphatase PTPL1; Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; PTP E1; PTP-E1; PTP1E; PTPL 1; PTPL1; PTPLE; PTPN 13; PTPN13; Tyrosine protein phosphatase non receptor type 13.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
FAP1,Fas相关磷酸酶1抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量273kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FAP1/PTPN13
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FAP1,Fas相关磷酸酶1抗体PubMedPubMed
产品介绍background:
PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.

Subunit:
Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus).

FAP1,Fas相关磷酸酶1抗体Subcellular Location:
Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium.

Tissue Specificity:
Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Contains 1 FERM domain.
Contains 1 KIND domain.
Contains 5 PDZ (DHR) domains.
Contains 1 tyrosine-protein phosphatase domain.

FAP1,Fas相关磷酸酶1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.