FITC标记的HEXIM2蛋白抗体
产品名称： FITC标记的HEXIM2蛋白抗体
英文名称： Anti-HEXIM2/FITC
产品编号： HZ-15469R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HEXIM2/FITC Conjugated antibody
FITC标记的HEXIM2蛋白抗体
| 英文名称 | Anti-HEXIM2/FITC |
| 中文名称 | FITC标记的HEXIM2蛋白抗体 |
| 别 名 | Hexamethylene bis-acetamide-inducible protein 2; Hexamthylene bis-acetamide inducible 2; HEXI2_HUMAN; hexim 2; HEXIM2; L3; Protein HEXIM2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 染色质和核信号 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HEXIM2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins, which inhibit Positive Transcription Elongation Factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit Cdk9 and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues. Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Subunit: Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed. Similarity: Belongs to the HEXIM family. Database links: Entrez Gene: 124790 Human SwissProt: Q96MH2 Human Unigene: 56382 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
六亚甲基双乙酰胺诱导型1(HEXIM1)和六亚甲基双乙酰胺诱导型2(HEXIM2)是一类通过与7SK结合抑制正转录延长因子b(P-TEFb)的蛋白质。P- TEFB由催化亚基CDK9和Cyclin T1或T2组成，作为调节亚基。该复合物在伸长水平上调节真核基因表达。HeXIM蛋白的C-端结构域相互直接相互作用。通过这些结构域，HEXIM1和HEXIM2形成稳定的均聚物和杂聚物，这可能有助于7SK小核糖核酸颗粒的形成。尽管HEXIM1和HEXIM2具有类似的功能，但它们在各种已建立的细胞系和人体组织中表现出不同的表达模式。