CNIH3,cornichon样蛋白抗体

产品编号HZ-8027R
英文名称CNIH3
中文名称cornichon样蛋白抗体
别 名Protein cornichon homolog 2: CNI like; CNIH 2; CNIH2; CNIH2_HUMAN; Cnih3; Cnil; Cornichon homolog 2 (Drosophila); Cornichon homolog 2; Cornichon like protein; Cornichon, Drosophila, homolog of, 2; Cornichon-like protein; Protein cornichon homolog 2; RGD1304930.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
CNIH3,cornichon样蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CNIH3/CNIH2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CNIH3,cornichon样蛋白抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.

Subunit:
Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with CACGN8 (By similarity). Interacts with GRIA1.

CNIH3,cornichon样蛋白抗体Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).

Similarity:
Belongs to the cornichon family.

Gene ID:
149111

Database links:
Entrez Gene: 149111 Human
Entrez Gene: 72978 Mouse
Entrez Gene: 690252 Rat
SwissProt: Q8TBE1 Human
Unigene: 28659 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.