FITC标记的富含亮氨酸重复蛋白8B抗体
产品名称： FITC标记的富含亮氨酸重复蛋白8B抗体
英文名称： Anti-LRRC8B/FITC
产品编号： HZ-18410R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LRRC8B/FITC Conjugated antibody
FITC标记的富含亮氨酸重复蛋白8B抗体
| 英文名称 | Anti-LRRC8B/FITC |
| 中文名称 | FITC标记的富含亮氨酸重复蛋白8B抗体 |
| 别 名 | KIAA 0231; leucine rich repeat containing 8 family, member B; MGC 42220; T cell activation leucine repeat rich protein; TA LRRP. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 92kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRRC8B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. Subcellular Location: Cell Membrane; multi-pass membrane protein. Database links: Entrez Gene: 23507 Human Entrez Gene: 433926 Mouse Entrez Gene: 305135 Rat Omim: 612888 Human SwissProt: Q6P9F7 Human SwissProt: Q5DU41 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
第1号染色体是最大的人类染色体，跨越2亿6000万个碱基对，占人类基因组的8%。1号染色体上约有3000个基因，考虑到基因数量众多，还有大量与1号染色体相关的疾病。值得注意的是，罕见的老化性疾病Hutchinson-Gilford progeria与编码层粘连蛋白A的LMNA基因有关。当有缺陷时，LMNA基因产物可在细胞核内积聚并引起特征性核小泡。迅速增强衰老的机制尚不清楚，是一个继续探索的话题。MutyH基因位于1号染色体上，是家族性腺瘤性息肉病的部分原因。Stutkle综合征、帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。在1q中发现了一个断点，它破坏了DISC1基因并与精神分裂症联系在一起。染色体1异常存在于各种癌症中，包括头颈癌、恶性黑色素瘤和多发性骨髓瘤。