FITC标记的细胞表面免疫球蛋白样转录因子2抗体
产品名称： FITC标记的细胞表面免疫球蛋白样转录因子2抗体
英文名称： Anti-LILRB1/FITC
产品编号： HZ-2634R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-LILRB1/FITC Conjugated antibody
| FITC标记的细胞表面免疫球蛋白样转录因子2抗体 |
| 英文名称 | Anti-LILRB1/FITC |
| 中文名称 | FITC标记的细胞表面免疫球蛋白样转录因子2抗体 |
| 别 名 | LILRB1; Leukocyte immunoglobulin-like receptor subfamily B member 1; Leukocyte immunoglobulin-like receptor 1; LIR-1; Immunoglobulin-like transcript 2; Monocyte/macrophage immunoglobulin-like receptor 7; ILT-2; MIR-7; CD85 antigen-like family member J; CD85j; ILT2; LIR1; MIR7; CD85; CD85 antigen; CD85j antigen; Ig like transcript 2; leukocyte Ig like receptor 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 72kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ILT2 (151-190aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Subunit: Binds PTPN6 when phosphorylated. Binds FCGR1A. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 10859 Human Omim: 604811 Human SwissProt: Q8NHL6 Human Unigene: 667388 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
Ⅰ类MHC抗原受体广泛识别HLA-A、HLA-B、HLA-C和HLA-G等位基因。H301/UL18受体，人巨细胞病毒Ⅰ类MHC同源物。配体结合导致抑制信号和下调免疫应答。LIRB1与I类MHC分子在自然杀伤细胞或T细胞上的结合保护靶细胞免于裂解。与HLA-B或HLA-E的相互作用导致对由FCIE1A触发的信号的抑制，并抑制5-羟色胺的释放。抑制FCGR1a介导的细胞蛋白磷酸化和胞内钙离子的动员。