Recombinant Murine FGF-Basic
 
Catalog Number:
AF-450-33
Synonyms:
Fibroblast Growth, Factor-basic, FGF-2, HBGF-2, Prostatropin
Description:
FGF-basic is one of 23 known members of the FGF family.  Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.  FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells.  FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4.  Recombinant murine FGF-basic is a 16.2 kDa protein consisting of 145 amino acid residues. Manufactured using all non-animal reagents.
AA Sequence:
MPALPEDGGA AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV DGVREKSDPH VKLQLQAEER GVVSIKGVCA NRYLAMKEDG RLLASKCVTE ECFFFERLES NNYNTYRSRK YSSWYVALKR TGQYKLGSKT GPGQKAILFL PMSAKS
Source:
E.coli
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by a cell proliferation assay using Balb/c 3T3 cells.  The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
 
 
 
 
Research Interests:
Angiogenesis/ Cardiovascular
Cancer
Cell Culture
FGF Superfamily
Inflammation
Neurobiology
Proliferation
Stem Cells & Differentiation
Wound Healing
 
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.