FITC标记的转录因子EYA1抗体
产品名称： FITC标记的转录因子EYA1抗体
英文名称： Anti-EYA1/FITC
产品编号： HZ-20158R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-EYA1/FITC Conjugated antibody
FITC标记的转录因子EYA1抗体
| 英文名称 | Anti-EYA1/FITC |
| 中文名称 | FITC标记的转录因子EYA1抗体 |
| 别 名 | BOP; BOR; Eya1; EYA1_HUMAN; eyes absent 1; eyes absent 1 homolog; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1; eyes absent homolog1; MGC141875 |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EYA1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: A gene on chromosome 8q13.3 encodes EYA1 (eyes absent), a protein with 16 exons. EYA1 is one of four members of the eyes absent family. A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family, while the PST (proline-serine-threonin)-rich amino terminal is highly divergent. EYA is expressed in flexor tendons and the developing central nervous system, kidney, eye and ear. EYA1 acts a transcriptional activator in connective tissue patterning through its PST domain, which functions as a transactivation domain. EYA1 plays a critical role in the development of the inner ear and kidney. EYA is involved in early inductive signaling, acting upstream of GDNF. EYA1 has been implicated in the autosomal dominant disorders branchio-oto-renal (BOR) syndrome and branhio-oto (BO) syndrome. Function: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Seems to coactivate SIX2, SIX4 and SIX5. May be required for normal development of branchial arches, ear and kidney. Subunit: Probably interacts with SIX2, SIX4 and SIX5. Subcellular Location: Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks. Tissue Specificity: In the embryo, highly expressed in kidney with lower levels in brain. Weakly expressed in lung. In the adult, highly expressed in heart and skeletal muscle. Weakly expressed in brain and liver. No expression in eye or kidney. Post-translational modifications: Sumoylated by SUMO1. DISEASE: Defects in EYA1 are the cause of branchiootorenal syndrome type 1 (BOR1) [MIM:113650]; also known as Melnick-Fraser syndrome. BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable. Defects in EYA1 are the cause of otofaciocervical syndrome (OFCS) [MIM:166780]. The syndrome is characterized by trophic alterations of the facies and shoulder girdle in addition to the malformations seen in BOR. Defects in EYA1 are the cause of branchiootic syndrome type 1 (BOS1) [MIM:602588]; also known as BO syndrome type 1 or branchiootic dysplasia. Individuals with BOS1 are affected by the same branchial and otic anomalies as those seen in individuals with BOR1, but lack renal anomalies. Similarity: Belongs to the HAD-like hydrolase superfamily. EYA family. Database links: Entrez Gene: 395718 Chicken Entrez Gene: 511188 Cow Entrez Gene: 477910 Dog Entrez Gene: 2138 Human Entrez Gene: 14048 Mouse Entrez Gene: 502935 Rat Omim: 601653 Human SwissProt: Q9YHA0 Chicken SwissProt: Q99502 Human SwissProt: P97767 Mouse Unigene: 491997 Human Unigene: 250185 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
染色体8q13.3上的一个基因编码EYA1（眼睛缺失），一种具有16个外显子的蛋白质。EYA1是四个眼睛缺失的家族成员之一。在眼缺失家族成员中，羧基末端的271个氨基酸结构域高度保守，而富含脯氨酸-丝氨酸-苏氨酸的氨基酸结构域高度发散。EYA在屈肌腱和发育中的中枢神经系统、肾脏、眼睛和耳朵中表达。EYA1通过其PST结构域在结缔组织模式化中起转录激活剂的作用，PST结构域作为反式激活结构域发挥作用。EYA1在内耳和肾脏的发育中起着关键性的作用。EYA参与早期诱导信号，作用于GDNF的上游。EYA1与常染色体显性遗传病分枝-耳-肾（BOR）综合征和脑-耳（BO）综合征有关。