FITC标记的前梯度同源蛋白2
产品名称： FITC标记的前梯度同源蛋白2
英文名称： Anti-Anterior Gradient 2/FITC
产品编号： HZ-5123R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Anterior Gradient 2/FITC Conjugated antibody
FITC标记的前梯度同源蛋白2
| 英文名称 | Anti-Anterior Gradient 2/FITC |
| 中文名称 | FITC标记的前梯度同源蛋白2 |
| 别 名 | HAG2; AG2 protein; hAG2; Secreted cement gland protein XAG2 homolog; AG 2; AG 2 protein; AG-2; AG2; AG2 protein; AGR 2; AGR2; AGR2_HUMAN; Anterior gradient 2 homolog (Xenopus laevis); anterior gradient 2 homolog; Anterior gradient protein 2 homolog; GOB 4; GOB4; HAG 2; hAG-2; hAG2; HAG2/R; HPC 8; HPC8; secreted cement gland homolog; Secreted cement gland protein XAG 2 homolog; Secreted cement gland protein XAG-2 homolog; Secreted cement gland protein XAG2 homolog; XAG 2; XAG2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Anterior Gradient 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: AGR2 is a member of the anterior gradient homolog family. It is the human ortholog of XAG-2, the secreted Xenopus laevis Anterior Gradient protein. In X. laevis, it is involved in cement gland differentiation and neural marker gene expression. AGR2 is a secretory protein encoded by two different AGR2 transcripts. It interacts with LYPD3 and ?dystroglycan (DAG-1). AGR2 is ubiquitously expressed with up-regulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR). AGR2 may serve as a potential therapeutic marker for various cancers. Function: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Subunit: Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Subcellular Location: Secreted. Endoplasmic reticulum. Tissue Specificity: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Similarity: Belongs to the AGR family. Database links: Entrez Gene: 10551 Human Entrez Gene: 23795 Mouse Entrez Gene: 298961 Rat Omim: 606358 Human SwissProt: O95994 Human SwissProt: O88312 Mouse Unigene: 530009 Human Unigene: 7244 Mouse Unigene: 98889 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
AGR2是前梯度同源家族的成员。这是人爪蟾前梯度蛋白XAG-2的人类直系同源物。在X. LaveS中，它参与了牙龈腺分化和神经标记基因表达。AGR2是由两个不同的AGR2转录物编码的分泌蛋白。它与LyPD3相互作用？肌萎缩蛋白（DAG-1）。AGR2在前列腺癌、乳腺癌、肺癌、肾癌和子宫内膜癌中普遍表达上调。AGR2表达与雌激素受体（ER）呈正相关，与表皮生长因子受体（EGFR）呈负相关。AGR2可作为各种癌症的潜在治疗标志物。