CGNL1,结蛋白样蛋白CGNL1抗体

产品编号HZ-13881R
英文名称CGNL1
中文名称结蛋白样蛋白CGNL1抗体
别 名Cgnl1; CGNL1_HUMAN; Cingulin like 1; Cingulin-like protein 1; FLJ14957; JACOP; Junction-associated coiled-coil protein; KIAA1749; MGC138254; Paracingulin.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 转录调节因子 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
CGNL1,结蛋白样蛋白CGNL1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量149kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CGNL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CGNL1,结蛋白样蛋白CGNL1抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

Function:
May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.

Subcellular Location:
Cell junction > tight junction. Localizes to the apical junction complex composed of tight and adherens junctions.

Tissue Specificity:
Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain.

DISEASE:
A chromosomal aberration involving CGNL1 is a cause of aromatase excess syndrome [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity. An inversion on inv(15)(q21.2;q21.3) moves the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region.

Similarity:
Belongs to the cingulin family.

Gene ID:
84952

Database links:
Entrez Gene: 84952 Human
Omim: 607856 Human
SwissProt: Q0VF96 Human
Unigene: 148989 Human

CGNL1,结蛋白样蛋白CGNL1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.