FGFR1OP,成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体

产品编号HZ-5712R
英文名称FGFR1OP
中文名称成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体
别 名FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 神经生物学 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Horse,
FGFR1OP,成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FGFR1OP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FGFR1OP,成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体PubMedPubMed
产品介绍background:
FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms.

Function:
Required for anchoring microtubules to the centrosomes.

Subunit:
Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.

FGFR1OP,成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin.

Tissue Specificity:
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.

DISEASE:
Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.

Similarity:
Belongs to the FGFR1OP family.
Contains 1 LisH domain.

Database links:
UniProtKB/Swiss-Prot: O95684.1

FGFR1OP,成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FGFR1OP蛋白最初是在引起干细胞骨髓增生病的癌蛋白中作为FGFR1的融合伴侣被发现的，目前研究认为，FGFR1OP蛋白在很多组织细胞中都有不同的存在，尤其是以脑, 心，肝，肌肉，肾，小肠，结肠，肾上腺，前列腺，睾丸和胰腺中高表达。