FITC标记的二脂酰甘油酰基转移酶抗体
产品名称： FITC标记的二脂酰甘油酰基转移酶抗体
英文名称： Anti-DGAT1/FITC
产品编号： HZ-2332R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DGAT1/FITC Conjugated antibody
FITC标记的二脂酰甘油酰基转移酶抗体
| 英文名称 | Anti-DGAT1/FITC |
| 中文名称 | FITC标记的二脂酰甘油酰基转移酶抗体 |
| 别 名 | ACAT related gene product 1; ACAT-related gene product 1; Acyl coenzyme A:cholesterol acyltransferase related gene 1; Acyl-CoA retinol O-fatty-acyltransferase; Acyl-CoA:diacylglycerol acyltransferase; ARAT; ARGP1; C75990; D15Ertd23e; Dgat; DGAT1; DGAT1_HUMAN; Diacylglycerol O acyltransferase 1; Diacylglycerol O-acyltransferase 1; Diglyceride acyltransferase; EC 2.3.1.20; hCG_24006; MGC139064; Retinol O fatty acyltransferase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DGAT1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. DGAT1 is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation. DGAT1 is involved in fat absorption in the intestine and in basal level triglyceride synthesis in adipose tissue, where it is more highly expressed. Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. Subunit: Homodimer or homotetramer. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Similarity: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. Database links: Entrez Gene: 482093 Dog Entrez Gene: 8694 Human Entrez Gene: 13350 Mouse Entrez Gene: 84497 Rat Omim: 604900 Human SwissProt: O75907 Human SwissProt: Q9Z2A7 Mouse SwissProt: Q9ERM3 Rat Unigene: 521954 Human Unigene: 22633 Mouse Unigene: 252 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
葡萄糖和胰岛素是合成代谢信号，上调一系列脂肪酶的转录，以将过量碳水化合物转化为甘油三酯以有效储存能量。DGAT1是帮助脂肪酸合成甘油三酯的微粒体酶。DGAT以甘油二酯（DAG）和脂肪酰基辅酶A为底物，催化甘油三酯合成中的端基和唯一的步骤。DGAT在细胞内的二酰基甘油代谢中起着基础性的作用，在高真核生物中对涉及甘油三酯代谢的生理过程（如肠脂肪吸收、脂蛋白组装、脂肪组织形成和哺乳）具有重要意义。DGAT1参与了脂肪吸收在肠道和基础水平甘油三酯合成脂肪组织，在那里它更高表达。