FITC标记的蛋白激酶MPK38抗体
产品名称： FITC标记的蛋白激酶MPK38抗体
英文名称： Anti-MELK/FITC
产品编号： HZ-12201R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MELK/FITC Conjugated antibody
FITC标记的蛋白激酶MPK38抗体
| 文名称 | Anti-MELK/FITC |
| 中文名称 | FITC标记的蛋白激酶MPK38抗体 |
| 别 名 | AI327312; HPK38; hMELK; HPK 38; hPK38; KIAA0175; Likely ortholog of maternal embryonic leucine zipper kinase; Maternal embryonic leucine zipper kinase; MELK; MELK_HUMAN; mKIAA0175; MPK38; OTTHUMP00000021377; OTTHUMP00000046113; pEg3 kinase; Protein kinase PK38; RP23 382O11.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 信号转导 干细胞 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 75kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human MELK/HPK38 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MELK a new member of the Snf1/AMPK family of kinases, encodes a protein with a kinase catalytic domain and a leucine zipper motif consisting of a periodic repetition of leucine residues at every seventh residue located within the N-terminal catalytic domain. This motif has been observed in myriad DNA-binding proteins and is presumed to be involved in protein-DNA interactions, and potentially protein-protein interactions. Research predicts that the gene product of MELK plays a role in the signal transduction events in the egg and early embryo. Mouse and human MELK proteins share 95% sequence identity in the kinase domain and northern blot analysis in mouse indicates that MELK expression is restricted to spermatogonia in the testis and to oocytes in the ovary. Function: Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis. Subunit: Monomer. Interacts with ZNF622 and PPP1R8. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in placenta, kidney, thymus, testis, ovary and intestine. Post-translational modifications: Autophosphorylated. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8. DISEASE: Note=Defects in MELK are associated with some cancers, such as brain or breast cancers. Expression is dramatically increased in aggressive undifferentiated tumors, correlating with poor patient outcome in breast and brain cancers, suggesting a role in tumor-initiating cells and proliferation via its function in cell proliferation regulation. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 KA1 (kinase-associated) domain. Contains 1 protein kinase domain. Database links: Entrez Gene: 9833 Human Entrez Gene: 17279 Mouse Entrez Gene: 520088 Cow Omim: 607025 Human SwissProt: Q14680 Human SwissProt: Q61846 Mouse Unigene: 184339 Human Unigene: 268668 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MELK是Snf1/AMPK激酶家族的新成员，编码具有激酶催化结构域和亮氨酸拉链基序的蛋白质，该基序由位于N端催化结构域内的每7个氨基酸残基上的亮氨酸残基周期性重复组成。这个基序已经在无数的DNA结合蛋白中观察到，并且推测它涉及蛋白质-DNA相互作用，以及潜在的蛋白质-蛋白质相互作用。研究表明，MELK基因产物在卵和早期胚胎的信号转导过程中起着重要作用。小鼠和人MELK蛋白在激酶结构域中具有95%的序列同源性，小鼠Northern印迹分析表明MELK的表达仅限于睾丸中的精原细胞和卵巢中的卵母细胞。