FITC标记的干扰素诱导跨膜蛋白1抗体
产品名称： FITC标记的干扰素诱导跨膜蛋白1抗体
英文名称： Anti-IFITM1/FITC
产品编号： HZ-1031R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-IFITM1/FITC Conjugated antibody
FITC标记的干扰素诱导跨膜蛋白1抗体
| 英文名称 | Anti-IFITM1/FITC |
| 中文名称 | FITC标记的干扰素诱导跨膜蛋白1抗体 |
| 别 名 | CD225; CD225 antigen; CD 225; CD-225; IFI17; Interferon induced protein 17; Interferon induced transmembrane protein 1; Interferon inducible protein 9-27; Interferon-induced protein 17; Interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu 13 antigen; Leu-13 antigen; LEU13; IFM1_HUMAN; Dispanin subfamily A member 2a; DSPA2a. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 11.7kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFITM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IFITM1 expression is induced by interferons alpha and gamma and it is thought to play a role in control of cell growth. It is upregulated in several tumor types and may be useful as a tumor biomarker. Function: IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals. Subunit: Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. Similarity: Belongs to the CD225 family. Database links: Entrez Gene: 8519 Human Entrez Gene: 68713 Mouse Entrez Gene: 293618 Rat Omim: 604456 Human SwissProt: P13164 Human SwissProt: Q9D103 Mouse Unigene: 458414 Human Unigene: 175661 Mouse Unigene: 22087 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IFITM1蛋白是蛋白复合物的组分之一,主要功能是参与同型粘附和抗增殖信号的转导,与细胞增殖、肿瘤分化、抗病毒、免疫监视等有关。IFITM-1主要用于消化系统肿瘤方面的研究，有学者认为：干扰素诱导跨膜蛋白1与干扰素结合，可以抑制肿瘤细胞的分化和增值 |
IFITM1的表达是由干扰素α和γ诱导的，它被认为在控制细胞生长中起作用。它在多种肿瘤类型中被上调，可能作为肿瘤生物标志物有用。