GDF8,生长分化因子8/肌肉抑制素抗体

产品编号HZ-1288G
英文名称GDF8
中文名称生长分化因子8/肌肉抑制素抗体
别 名MSTN; growth differntiation factor 8; GDF 8; Growth differentiation factor 8; Growth/Differentiation Factor 8; myostatin; GDF8_HUMAN.
说 明 书0.1ml 0.2ml
研究领域免疫学 生长因子和激素 细胞分化
抗体来源Goat
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow,
GDF8,生长分化因子8/肌肉抑制素抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12/43kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GDF8
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GDF8,生长分化因子8/肌肉抑制素抗体PubMedPubMed
产品介绍background:
Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.

Function:
Acts specifically as a negative regulator of skeletal muscle growth.

Subunit:
Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.

Subcellular Location:
Secreted.

Tissue Specificity:
Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the adult, highest expression is seen in the gastrointestinal tract, brain, muscle, heart and testis. Also expressed in the adult pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary.

GDF8,生长分化因子8/肌肉抑制素抗体DISEASE:
Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.

Similarity:
Belongs to the TGF-beta family.

Database links:
UniProtKB/Swiss-Prot: O14793.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GDF-8又称MSTN,是转化生长因子超家族，也是近年来发现的一类重要的肌细胞生长调控因子，它通过抑制MyoD家族成员转录活性负向控制肌细胞的生长发育，它的表达量与肌肉重量的变化呈负相关。