FITC标记的L型电压依赖型钙通道β4抗体
产品名称： FITC标记的L型电压依赖型钙通道β4抗体
英文名称： Anti-CACNB4/FITC
产品编号： HZ-11983R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CACNB4/FITC Conjugated antibody
FITC标记的L型电压依赖型钙通道β4抗体
| 英文名称 | Anti-CACNB4/FITC |
| 中文名称 | FITC标记的L型电压依赖型钙通道β4抗体 |
| 别 名 | CAB4; L-type Ca++ CPβ4; CACB4_HUMAN; Cacnb4; CACNLB4; Calcium channel voltage dependent beta 4 subunit; Calcium channel voltage dependent subunit beta 4; Calcium channel voltage-dependent subunit beta 4; Dihydropyridine sensitive L type calcium channel beta 4 subunit; EA5; EIG9; EJM; EJM4; Voltage-dependent L-type calcium channel subunit beta-4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CACNB4/L-type Ca++ CPβ4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta 4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta 4, also known as CACNB4 (Calcium channel voltage-dependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 4 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta4 exist due to alternative splicing events. Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Subunit: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG. Tissue Specificity: Expressed predominantly in the cerebellum and kidney. DISEASE: Genetic variations in CACNB4 are the cause of susceptibility to idiopathic generalized epilepsy type 9 (IGE9) [MIM:607682]. IGE9 is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Genetic variations in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682]. EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Similarity: Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain. Database links: Entrez Gene: 785 Human Entrez Gene: 12298 Mouse Entrez Gene: 58942 Rat Omim: 601949 Human SwissProt: O00305 Human SwissProt: Q8R0S4 Mouse Unigene: 120725 Human Unigene: 330223 Mouse Unigene: 472778 Mouse Unigene: 9863 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
电压依赖性钙通道对于释放神经递质是必需的。L型（长持续电流）电压依赖性钙通道由四个亚基组成：α1亚基、β亚基、β亚基和Alpha2γ亚基。Beta亚基由四个基因编码，命名为Beta1-Beta 4，所有这些基因都有助于钙电流的多样性，并参与Beta亚基的膜运输。L型Ca++CPβ4，又称CACNB4（钙通道电压依赖性亚基β4），CACNLB4或CAB4，是一种484氨基酸蛋白，含有一个SH3结构域，在卵巢、大脑和平滑肌中表达。作为Beta亚基的四个组成部分之一，L-型Ca++CP Beta 4增加电压依赖性钙通道中的峰值钙电流，从而改变激活和失活的电压依赖性，并控制G蛋白抑制和Beta膜靶向。由于选择性剪接事件的存在，L型Ca++CP-BETA4存在两种异构体。