Human, Murine & Rat Neurotrophins
            
Recombinant Human BDNF
            

            

             
        
        

            
 
            

            

                

                    

                        

                        
Synonyms :
                        
                        

                        
Brain Derived Neurotrophic Factor
                        
                    
                    

                        

                        
Description :
                        
                        

                        
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.
                        
                    
                    

                        

                        
Catalog #:
                        
                        

                        
450-02
                        
                    
                    

                        

                        
Source :
                        
                        

                        
E.coli
                        
                    
                    

                        

                        
Purity :
                        
                        

                        
Greater than 98% by SDS-PAGE gel and HPLC analyses.
                        
                    
                    

                        

                        
Endotoxin Level :
                        
                        

                        
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
                        
                    
                    

                        

                        
Biological Activity :
                        
                        

                        
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
                        
                    
                    

                        

                        
Selected References :
                        
                        

                        
Selected List of References Citing This PeproTech Product
                        
                    
                    

                        

                        
AA Sequence :
                        
                        

                        
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR 
                        
                    
                    

                        

                        
PubMed Link :
                        
                        

                        
BDNF+AND+human
                        
                    
                    

                        

                        
Country of Origin :
                        
                        

                        
USA
                        
                    
                    

                        
 
                        

                        
                    
                    

                        

                        
 
                        
                        

                        

                        

                            

                                

                                    
Size A
                                    
2μg
                                    
$80 
                                    
 
                                
                                

                                    
 
                                
                                

                                    
Size B
                                    
10μg
                                    
$195 
                                    
 
                                
                                

                                    
 
                                
                                

                                    
Size C
                                    
1mg
                                    
$5200 
                                    
 
                                
                                

                                    
 
                                
                            
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
Special Sizes: 

                        Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
                        
                    
                    

                        

                        
 
                        
                        

                        
Usage:

                        For Research Use Only. Not for use in diagnostic or therapeutic procedures.