CYP11A1,细胞色素P450 11A1抗体-抗体-抗体-生物在线
上海沪震实业有限公司
CYP11A1,细胞色素P450 11A1抗体

CYP11A1,细胞色素P450 11A1抗体

商家询价

产品名称: CYP11A1,细胞色素P450 11A1抗体

英文名称: Anti-CYP11A1 antibody

产品编号: HZ-10099R

产品价格: null

产品产地: 中国/美国

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB,ELISA,IHC-P,IHC-F,IF

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749 点击查看
  • 传真 : 点击查看
  • 邮箱 : www.shzbio.net
  • 二维码 : 点击查看

CYP11A1,细胞色素P450 11A1抗体

产品编号HZ-10099R
英文名称CYP11A1
中文名称细胞色素P450 11A1抗体
别 名Cholesterol 20 22 desmolase; Cholesterol desmolase; Cholesterol monooxygenase (side chain cleaving); Cholesterol side chain cleavage enzyme; CYP 11A; CYP11A; CYPXIA1; Cytochrome P450 11A1; Cytochrome P450 11A1 mitochondrial; Cytochrome P450 family 11 subfamily A polypeptide 1; Cytochrome P450 subfamily XIA (cholesterol side chain cleavage); Cytochrome P450 subfamily XIA; Cytochrome P450C11A1; P450(scc); P450SCC; Steroid 20 22 lyase.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 53/57
CYP11A1,细胞色素P450 11A1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53/57kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CYP11A1/P450SCC
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CYP11A1,细胞色素P450 11A1抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]

Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

Subcellular Location:
Mitochondrion membrane.

DISEASE:
Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR) [MIM:613743]. A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia.

Similarity:
Belongs to the cytochrome P450 family.

Gene ID:
1583

CYP11A1,细胞色素P450 11A1抗体Database links:
Entrez Gene: 1583 Human
Entrez Gene: 13070 Mouse
Entrez Gene: 29680 Rat
Omim: 118485 Human
SwissProt: Q2XV99 Cynomolgus Monkey
SwissProt: P05108 Human
SwissProt: Q9QZ82 Mouse
SwissProt: P14137 Rat
Unigene: 303980 Human
Unigene: 302865 Mouse
Unigene: 1401 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.