FITC标记的Hemk甲基转移酶家族2号蛋白抗体
产品名称： FITC标记的Hemk甲基转移酶家族2号蛋白抗体
英文名称： Anti-HEMK2/FITC
产品编号： HZ-15453R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HEMK2/FITC Conjugated antibody
FITC标记的Hemk甲基转移酶家族2号蛋白抗体
| 英文名称 | Anti-HEMK2/FITC |
| 中文名称 | FITC标记的Hemk甲基转移酶家族2号蛋白抗体 |
| 别 名 | C21orf127; Chromosome 21 open reading frame 127; EC 2.1.1.-; HemK methyltransferase family member 2; HemK2; M.HsaHemK2P; MGC19995; MTQ2; N-6 adenine-specific DNA methyltransferase 1; N-6 adenine-specific DNA methyltransferase 1 (putative); N6-DNA-methyltransferase; N6AMT; N6AMT1; OTTHUMP00000096393; OTTHUMP00000096394; PRED28; HEMK2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 染色质和核信号 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HEMK2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HEMK2 is a 214 amino acid protein that belongs to the methyltransferase superfamily and exists as multiple alternatively spliced isoforms. The gene encoding HEMK2 maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21). Function: Heterodimeric methyltransferase that catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. Subunit: Heterodimer with TRMT112. Tissue Specificity: Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. Similarity: Belongs to the eukaryotic/archaeal PrmC-related family. Database links: UniProtKB/Swiss-Prot: Q9Y5N5.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
HEMK2是属于甲基转移酶超家族的214个氨基酸，以多个交替剪接的亚型存在。编码HEMK2的基因映射到人类21号染色体，其包含大约300个基因，并且包含人类基因组的近1.5%。21号染色体相关的疾病包括阿尔茨海默病、肌萎缩侧索硬化症和最显著的唐氏综合征（也称为21三体综合征）。