FITC标记的脑蛋白CG6抗体
产品名称： FITC标记的脑蛋白CG6抗体
英文名称： Anti-Brain protein CG6/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Brain protein CG6/FITC Conjugated antibody
FITC标记的脑蛋白CG6抗体
| 产品编号 | bs-9492R-FITC |
| 英文名称 | Anti-Brain protein CG6/FITC |
| 中文名称 | FITC标记的脑蛋白CG6抗体 |
| 别 名 | Brain protein CG 6; Brain protein CG-6; Brain protein CG6; C9orf4; CG 6; CG6; chromosome 9 open reading frame 4; CI004_HUMAN; Uncharacterized protein C9orf4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Brain protein CG6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: C9orf4 is a 344 amino acid single-pass membrane protein that is primarily expressed in adult and fetal brain and is weakly expressed in spinal cord, adult ovary and medulla. C9orf4 contains one DOMON domain, a predominantly β-sheet domain that is thought to aide in extracellular adhesion. The gene encoding C9orf4 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. Subunit: Component of the outer core of AMPAR complex. AMPARcomplex consists of an inner core made of 4 pore-forming GluA/GRIAproteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliarysubunits arranged in a twofold symmetry. One of the two pairs ofdistinct binding sites is occupied either by CNIH2, CNIH3 orCACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 orGSG1L. This inner core of AMPAR complex is complemented by outercore constituents binding directly to the GluA/GRIA proteins atsites distinct from the interaction sites of the inner coreconstituents. Outer core constituents include at least PRRT1,PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the innerand outer core serve as a platform for other, more peripherallyassociated AMPAR constituents. Alone or in combination, theseauxiliary subunits control the gating and pharmacology of the AMPARcomplex and profoundly impact their biogenesis and proteinprocessing (By similarity). Subcellular Location: Cell membrane (By similarity). Celljunction, synapse (By similarity). Tissue Specificity: Expressed in adult and fetal brain. Very weak expression in medulla, spinal cord and in adult ovary. Similarity: Contains 1 DOMON domain. Database links: Entrez Gene: 23732 Human Omim: 604574 Human SwissProt: Q9P0K9 Human Unigene: 347537 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
C9OFF4是一种344氨基酸单程膜蛋白，主要在和胎儿脑中表达，在脊髓、卵巢和髓质中呈弱表达。C9OFF4包含一个多蒙结构域，主要是β-片状结构域，被认为是细胞外粘附的载体。编码c9Orf4的基因定位于人类染色体9，由约1亿4500万个碱基和4%个人类基因组组成，编码近900个基因。认为在性别决定中起作用的是，9P末端的缺失可导致男性与女性性别逆转的发展，一个具有男性X、Y基因型的女性的表型。遗传性出血性毛细血管扩张症，其特征是由有害的血管缺陷，与编码EngGLN蛋白的染色体9基因有关。家族性失代偿也通过基因IKBKAP与9号染色体相关。值得注意的是，9号染色体包含最大的干扰素家族基因簇。染色体9与易位的22号染色体相关，导致BCR-ABL融合蛋白在白血病中的异常生成。