疼痛miRNAPCR芯片主要用于研究参与转导、维护和调节疼痛反应的84个 miRNA的表达。有害环境刺激、组织损伤和疾病都会引起疼痛。因为在任何给定的时间它影响多达20%的人口,疼痛提供了一个巨大的治疗靶标和途径去了解神经系统功能的分子机制。尽管神经性疼痛经常来自末梢区域 (PNS) 的损伤或中枢神经系统 (CNS)的损伤,外周组织损伤和/或炎症通常启动炎性疼痛。神经性和炎症性疼痛都能引起感觉神经(痛觉受器)受损，刺激皮肤,肌肉和内脏和终止脊髓背角的薄片。疼痛信号的转导需要特定的蛋白的表达,如离子通道和神经递质受体。因为miRNA应该调节基因编码疼痛分子途径的组件,研究人员推测,它们可能对疼痛调制主开关至关重要。更好地理解其在调节痛觉和疼痛通路重要性和作用,几个miRNA分析实验已证明miRNA在啮齿动物疼痛模型中差异表达，如挫伤性脊髓损伤、肌肉疼痛、发炎、缺血再灌注损伤。miRNA在疼痛综合征患者血液复杂区域的差异表达,表明miRNA也可能是有价值的疼痛生物标记。这些研究中差异表达的miRNA也被证明和/或预测调节基因参与疼痛分子机制如细胞凋亡和炎症等。这个芯片分析已发现在典型疼痛模型中差异表达的miRNA的表达。每张芯片含一个对照组使得分析数据时可以用相对定量ΔΔCT方法评估逆转录效率,基因组DNA污染,和PCR效率。利用这张芯片，通过实时定量PCR，可以简易且可靠地分析与疼痛相关的miRNA的表达。

miScript miRNA PCR芯片仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。

提供96孔板——384 -(4 x 96)板,和100孔板

Upregulated by Pain:
Upregulated by Contusive Spinal Cord Injury: miR-1, miR-145-5p, miR-146a-5p, miR-146b-5p, miR-152-3p, miR-15b-5p, miR-17-5p, miR-199a-3p, miR-203a, miR-206, miR-20a-5p, miR-20b-5p, miR-214-3p, miR-21-5p, miR-223-3p, miR-30a-3p, miR-31-5p, miR-374b-5p, miR-378a-3p, miR-92a-3p, miR-92b-3p, miR-98-5p.
Upregulated by Ischemia-Reperfusion Injury: miR-132-5p, miR-133a-3p, miR-204-3p, miR-323a-3p, miR-365b-3p, miR-369-5p, miR-376b-5p, miR-505-5p, miR-665.

Downregulated by Pain:
Downregulated by Contusive Spinal Cord Injury:miR-129-2-3p, miR-137, miR-138-5p, miR-219a-2-3p, miR-219a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-323a-3p, miR-338-5p, miR-34a-5p, miR-379-3p, miR-495-3p, miR-543.
Downregulated by Inflammatory Pain:miR-10a-5p, miR-124-3p, miR-134-5p, miR-183-5p, miR-29a-3p, miR-98-5p, miR-99a-5p.
Downregulated by Ischemia-Reperfusion Injury:miR-146a-5p, miR-199a-3p, miR-210-3p.

Regulated by Pain:
Regulated by Contusive Spinal Cord Injury:miR-100-5p, miR-103a-3p, miR-107, miR-124-3p, miR-127-3p, miR-128-3p, miR-133a-3p, miR-133b, miR-154-5p, miR-181a-5p, miR-451a, miR-487b-3p, miR-99a-5p.

Complex Regional Pain Syndrome:miR-106b-5p, miR-126-3p, miR-130b-3p, miR-132-3p, miR-142-5p, miR-155-5p, miR-16-5p, miR-181a-5p, miR-20a-5p, miR-20b-5p, miR-221-3p, miR-25-3p, miR-93-5p.

Responsive to Antiinflammatories:miR-142-3p, miR-146b-5p, miR-203a, miR-208a-3p, miR-21-5p, miR-219a-2-3p, miR-219a-5p, miR-302d-3p.

Responsive to Neuroprotection:miR-199a-3p, miR-210-3p, miR-219a-2-3p, miR-323a-3p, miR-324-5p, miR-331-5p, miR-365b-3p, miR-369-5p, miR-376b-5p, miR-7-5p.

Apoptosis:miR-1, miR-106b-5p, miR-125b-5p, miR-128-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-183-5p, miR-199a-3p, miR-203a, miR-206, miR-20a-5p, miR-210-3p, miR-214-3p, miR-21-5p, miR-221-3p, miR-25-3p, miR-29a-3p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-31-5p, miR-323a-3p, miR-34a-5p, miR-34c-5p, miR-365b-3p, miR-378a-3p, miR-451a, miR-7-5p, miR-92a-3p, miR-98-5p.

Inflammation:miR-106b-5p, miR-125b-5p, miR-127-3p, miR-128-3p, miR-130b-3p, miR-145-5p, miR-146a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-199a-3p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-210-3p, miR-23b-3p, miR-29a-3p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-323a-3p, miR-34a-5p, miR-34c-5p, miR-365b-3p, miR-543, miR-93-5p, miR-98-5p, miR-99a-5p.

Associated with Neuropathic Pain in Specific Cells:
Amygdala:miR-182-5p, miR-34c-5p.
Dorsal Root Ganglia Nociceptor:miR-103a-3p, miR-133a-3p, miR-134-5p, miR-143-3p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-7-5p.
Hippocampus:miR-125b-5p, miR-132-5p.
Immune Cells:miR-124-3p, miR-132-5p.
Insular Cortex:miR-133b.
Prefrontal Cortex:miR-181a-5p, miR-223-3p.
Spinal Dorsal Horn:miR-103a-3p, miR-124-3p, miR-134-5p, miR-23b-3p.

Other miRNA Involved in Pain:miR-339-5p, miR-96-5p.